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Guidelines

MIRAGE

ribonuclease T2

Summary

Gene Symbol

RNASET2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8635

PubChem

8635

Alliance of Genome Resources

HGNC:21686

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Disulfide bond
Endonuclease
Endoplasmic reticulum
Glycoprotein
Innate immunity
Lyase
Lysosome
Mitochondrion
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O00584	Ribonuclease 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
RNA catabolic process	IDA	22735700
RNA catabolic process	IBA
innate immune response	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IBA
extracellular space	IDA	16620762
extracellular space	HDA	16502470
mitochondrial intermembrane space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

endoplasmic reticulum lumen

organelle envelope lumen [inference]

mitochondrial intermembrane space

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
RNA binding	IEA
RNA endonuclease activity	IBA
RNA nuclease activity	IDA	22735700
ribonuclease T2 activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

RNA endonuclease activity

ribonuclease T2 activity

RNA nuclease activity

RNA endonuclease activity

ribonuclease T2 activity

lyase activity [inference]

phosphorus-oxygen lyase activity [inference]

ribonuclease T2 activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity

RNA endonuclease activity

ribonuclease T2 activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ribonuclease

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
RNA catabolic process
RNA endonuclease activity
ribonuclease T2 activity

Displaying **all 5** entries
InterPro
Ribonuclease T2, His active site 1
Ribonuclease T2, His active site 2
Ribonuclease T2, eukaryotic
Ribonuclease T2-like superfamily
Ribonuclease T2-like

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:0081007	RNASET2-deficient cystic leukoencephalopathy	Alliance of Genome Resources
DOID:0112182	mismatch repair cancer syndrome	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:3883	Lynch syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Papio anubis	101023142		PAPAN34724
Saimiri boliviensis boliviensis	101032545		SAIBB22661
Felis catus	101080386		FELCA12165
Ovis aries	101114785		SHEEP18964
Gorilla gorilla gorilla	101136020		GORGO36133
Oryzias latipes	101163650		ORYLA12493
Tursiops truncatus	101338807		TURTR12881
Octodon degus	101590709		OCTDE24905
Ficedula albicollis	101818234		FICAL03429
Melopsittacus undulatus	101881198		MELUD07286

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025