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dynein axonemal heavy chain 11

Summary

Gene Symbol

DNAH11

Organism

Homo sapiens (human)

External Links

NCBI Gene

8701

PubChem

8701

Alliance of Genome Resources

HGNC:2942

Annotation

Keyword

ATP-binding
Cilium
Coiled coil
Cytoskeleton
Disease variant
Dynein
Kartagener syndrome
Microtubule
Motor protein
Reference proteome
Repeat

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q96DT5	Axonemal beta dynein heavy chain 11 Ciliary dynein heavy chain 11
H9NAJ7
H9NAJ8
Q96NT7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cilium movement involved in cell motility	IBA
epithelial cilium movement involved in determination of left/right asymmetry	IEA
determination of left/right asymmetry in nervous system	IEA
regulation of cilium beat frequency	IMP	18022865 22184204 22499950
protein localization to motile cilium	IMP	33139725

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

cilium movement involved in cell motility

flagellated sperm motility

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium [inference]

protein localization to motile cilium

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

determination of left/right asymmetry in nervous system

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac septum morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium [inference]

protein localization to motile cilium

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium [inference]

protein localization to motile cilium

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of cilium movement [inference]

regulation of cilium beat frequency

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
microtubule	IEA
dynein complex	IBA
9+2 motile cilium	IBA IDA	26909801
9+0 motile cilium	IEA
motile cilium	IDA	31178125

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex

catalytic complex [inference]

dynein complex

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

proximal portion of axoneme

Displaying **all 5** entries
GO Term	Evidence Code	PMID
minus-end-directed microtubule motor activity	IBA
dynein intermediate chain binding	IBA
ATP hydrolysis activity	IEA
dynein light intermediate chain binding	IBA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dyneins heavy chain

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Kelch-type beta propeller

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050144	Kartagener syndrome	Alliance of Genome Resources
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0050651	atrioventricular septal defect	Alliance of Genome Resources
DOID:0110605	primary ciliary dyskinesia 7	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 50 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ovis aries	101120490		SHEEP15361
Gorilla gorilla gorilla	101149995	9595_0:0024a8	GORGO38137
Tursiops truncatus	101325585		TURTR13442
Octodon degus	101584091		OCTDE03893
Mustela putorius furo	101673236		MUSPF17474
Chrysemys picta bellii	101939436		CHRPI33061
Ictidomys tridecemlineatus	101956377		ICTTR09842
Chinchilla lanigera	102006882		CHILA02894
Macaca fascicularis	102142064		MACFA29711
Chlorocebus sabaeus	103226396		CHLSB09722

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Annotation

OrthoDB (Group)

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Acknowledgements