GlyCosmos Portal

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
DNA binding	IBA
satellite DNA binding	TAS	9774669
DNA endonuclease activity	TAS	10097147
endodeoxyribonuclease activity	TAS	10097147
protein binding	IPI	12702765 23275563 32296183 32814053

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

endodeoxyribonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

pyrimidine-specific mismatch base pair DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

pyrimidine-specific mismatch base pair DNA N-glycosylase activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

satellite DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

satellite DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

methyl-CpG-binding domain protein 4

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
DNA repair
catalytic activity

Displaying **all 2** entries
InterPro
DNA glycosylase
Methyl-CpG binding protein MeCP2/MBD4

Human Protein Atlas

ENSG00000129071

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:6039	uveal melanoma	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 11 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0002858	Meningioma
HP:0003003	Colon cancer
HP:0003581	Adult onset
HP:0003596	Middle age onset
HP:0003621	Juvenile onset
HP:0004808	Acute myeloid leukemia
HP:0005227	Adenomatous colonic polyposis
HP:0007716	Uveal melanoma
HP:0011462	Young adult onset

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:619975	tumor predisposition syndrome 2
OMIM:606660	melanoma, uveal, susceptibility to, 1

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Tumor predisposition syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

ChIP-Atlas

Target Genes: Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for MBD4
Distance from TSS: ± 10 kb

Displaying entries **11 - 20** of **187** in total

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Gene Symbol	Description	Cellline (score)
XXYLT1	xyloside xylosyltransferase 1	Hep_G2(102)
DPM1	dolichyl-phosphate mannosyltransferase subunit 1, catalytic	Hep_G2(113)
SPAG1	sperm associated antigen 1	Hep_G2(149)
PIGO	phosphatidylinositol glycan anchor biosynthesis class O	Hep_G2(118)
TMTC3	transmembrane O-mannosyltransferase targeting cadherins 3	Hep_G2(98)
SLC35B1	solute carrier family 35 member B1	Hep_G2(168)
ALG1	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Hep_G2(108)
PIGF	phosphatidylinositol glycan anchor biosynthesis class F	Hep_G2(65)
SLC35A3	solute carrier family 35 member A3	Hep_G2(159)
GDPD1	glycerophosphodiester phosphodiesterase domain containing 1	Hep_G2(113)

Colocalization: Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for MBD4

Displaying **all 4** entries
Gene Symbol	Description	Cellline (score)
INSR	insulin receptor	Hep_G2(0)
HDAC2	histone deacetylase 2	Hep_G2(9)
INO80	INO80 complex ATPase subunit	Hep_G2(0) HuH-7(0)
MBD4	methyl-CpG binding domain 4, DNA glycosylase	Hep_G2(10)

An integrative, comprehensive database to explore public Epigenetic dataset, including ChIP-Seq, DNase-Seq, ATAC-Seq, and Bisulfite-Seq data: ChIP-Atlas covers almost all public data archived in Sequence Read Archive of NCBI, EBI, and DDBJ with over 224,000 experiments.

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements