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WASP family member 1

Summary

Gene Symbol

WASF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

8936

PubChem

8936

Alliance of Genome Resources

HGNC:12732

Annotation

Keyword

3D-structure
Actin-binding
Cell junction
Cytoskeleton
Disease variant
Epilepsy
Intellectual disability
Methylation
Phosphoprotein
Reference proteome
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92558	Protein WAVE-1 Verprolin homology domain-containing protein 1 Wiskott-Aldrich syndrome protein family member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
actin filament polymerization	TAS	9843499
cellular response to brain-derived neurotrophic factor stimulus	ISS
modification of postsynaptic actin cytoskeleton	IEA
Rac protein signal transduction	IMP	21107423
actin cytoskeleton organization	IBA IMP	29961568

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

protein-containing complex assembly

protein polymerization [inference]

actin filament polymerization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium morphogenesis

cell junction organization [inference]

synapse organization [inference]

modification of synaptic structure [inference]

modification of postsynaptic structure [inference]

modification of postsynaptic actin cytoskeleton

protein-containing complex organization [inference]

protein-containing complex assembly

protein polymerization [inference]

actin filament polymerization

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament polymerization

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

dendrite extension

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
lamellipodium	IBA
SCAR complex	IBA IMP	21107423
protein-containing complex	IDA	25097019
actin cytoskeleton	TAS	9843499
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex

SCAR complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

postsynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein kinase A binding	IPI	25097019
actin binding	IEA
protein kinase A regulatory subunit binding	IBA
protein binding	IPI	11130076 24439377 25416956 28514442 32296183 33961781 35271311 9843499
small GTPase binding	IMP	21107423

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

protein kinase A binding

protein kinase A regulatory subunit binding

protein-containing complex binding [inference]

Arp2/3 complex binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8936	Xenbase:XB-GENE-978145
Drosophila melanogaster	10163	FB:FBgn0041781
Mus musculus	83767	Xenbase:XB-GENE-978145	MOUSE00598
Drosophila melanogaster	242687	FB:FBgn0041781
Rattus norvegicus	294568	Xenbase:XB-GENE-978145	RATNO22532
Pan troglodytes	462935		PANTR38852
Canis lupus familiaris	475024		CANLF03059
Bos taurus	531488		BOVIN35549
Macaca mulatta	699042		MACMU35399
Monodelphis domestica	100022094		MONDO12862