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WASP family member 1

Summary

Gene Symbol

WASF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

8936

PubChem

8936

Alliance of Genome Resources

HGNC:12732

Annotation

Keyword

3D-structure
Actin-binding
Cell junction
Cytoskeleton
Disease variant
Epilepsy
Intellectual disability
Methylation
Phosphoprotein
Reference proteome
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92558	Protein WAVE-1 Verprolin homology domain-containing protein 1 Wiskott-Aldrich syndrome protein family member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
actin filament polymerization	TAS	9843499
positive regulation of neurotrophin TRK receptor signaling pathway	IEA
protein-containing complex assembly	NAS	10381382
lamellipodium morphogenesis	IMP	29961568
dendrite extension	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

protein-containing complex assembly

protein polymerization [inference]

actin filament polymerization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium morphogenesis

cell junction organization [inference]

synapse organization [inference]

modification of synaptic structure [inference]

modification of postsynaptic structure [inference]

modification of postsynaptic actin cytoskeleton

protein-containing complex organization [inference]

protein-containing complex assembly

protein polymerization [inference]

actin filament polymerization

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament polymerization

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

dendrite extension

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
mitochondrial outer membrane	IEA
cytosol	TAS
cytoskeleton	TAS	10970852
focal adhesion	IEA
actin cytoskeleton	TAS	9843499

GO Hierarchy

cellular component

protein-containing complex

SCAR complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

postsynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
actin binding	IEA
protein binding	IPI	11130076 24439377 25416956 28514442 32296183 33961781 35271311 9843499
small GTPase binding	IMP	21107423
protein kinase A regulatory subunit binding	IBA
protein kinase A binding	IPI	25097019

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

protein kinase A binding

protein kinase A regulatory subunit binding

protein-containing complex binding [inference]

Arp2/3 complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

wiskott-Aldrich syndrome protein family member

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Arp2/3 complex binding
actin binding
actin cytoskeleton organization
positive regulation of Arp2/3 complex-mediated actin nucleation
protein kinase A regulatory subunit binding

Displaying **all 2** entries
InterPro
SCAR/WAVE family
WH2 domain

Ortholog

Displaying entries **71 - 80** of 97 in total

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Species	Gene ID	Orthologous MAtrix
Ictalurus punctatus	108261263	ICTPU25734
Pygocentrus nattereri	108443247	PYGNA29143
Rhinopithecus bieti	108540547	RHIBE13753
Cyprinus carpio carpio	109097762	CYPCA83928
Crocodylus porosus	109311930	CROPO09281
Hippocampus comes	109518133	HIPCM18189
Phascolarctos cinereus	110222862	PHACI12248
Sus scrofa	110256054	PIGXX13828
Seriola dumerili	111239134	SERDU01846
Vulpes vulpes	112925169	VULVU19152