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gamma-glutamyltransferase light chain 2

Summary

Gene Symbol

GGTLC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

91227

PubChem

91227

Alliance of Genome Resources

HGNC:18596

Annotation

Keyword

Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q14390	Gamma-glutamyltransferase light chain 2 Gamma-glutamyltransferase-like protein 4
A0A494C1J8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
biological_process	ND
glutathione catabolic process	IEA
leukotriene D4 biosynthetic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

catabolic process [inference]

organic substance catabolic process [inference]

glutathione catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

glutathione metabolic process [inference]

glutathione catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic substance catabolic process [inference]

glutathione catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

leukotriene D4 biosynthetic process

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
glutathione hydrolase activity	IEA
molecular_function	ND

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

omega peptidase activity [inference]

glutathione hydrolase activity

threonine-type peptidase activity [inference]

glutathione hydrolase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

omega peptidase activity [inference]

glutathione hydrolase activity

threonine-type peptidase activity [inference]

glutathione hydrolase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Gamma-glutamyltranspeptidase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
glutathione catabolic process
glutathione hydrolase activity
hydrolase activity
transferase activity

Displaying **all 4** entries
InterPro
Gamma-glutamyltranspeptidase, large subunit, C-terminal domain
Gamma-glutamyltranspeptidase, small subunit
Gamma-glutamyltranspeptidase
Nucleophile aminohydrolases, N-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:5022	aflatoxins-related hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 26 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	794105		ZFIN:ZDB-GENE-121214-50
Drosophila melanogaster	5740847		FB:FBgn0025837
Pongo abelii	100441416	9601_0:0050b1
Nomascus leucogenys	100592068			NOMLE34345
Nomascus leucogenys	100593662			NOMLE34345
Pan troglodytes	100610580	9598_0:00531d		PANTR49510
Gorilla gorilla gorilla	101152651	9595_0:00525b		GORGO22851
Pan troglodytes	107966459	9598_0:00534c		PANTR49562
Gorilla gorilla gorilla	109024567	9595_0:0055b3
Pan paniscus	117977384	9597_0:00549f

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024