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nexilin F-actin binding protein

Summary

Gene Symbol

NEXN

Organism

Homo sapiens (human)

External Links

NCBI Gene

91624

PubChem

91624

Alliance of Genome Resources

HGNC:29557

Annotation

Keyword

Actin-binding
Alternative splicing
Cardiomyopathy
Cell junction
Coiled coil
Cytoskeleton
Disease variant
Immunoglobulin domain
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DDI0
Q0ZGT2	F-actin-binding protein Nelin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
homophilic cell adhesion via plasma membrane adhesion molecules	IBA
axon guidance	IBA
regulation of cell migration	IDA	15823560
regulation of cytoskeleton organization	IEP	15823560
dendrite self-avoidance	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cell recognition [inference]

neuron recognition [inference]

dendrite self-avoidance

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization

regulation of cell motility [inference]

regulation of cell migration

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA
plasma membrane	IBA
adherens junction	IEA
focal adhesion	IBA
focal adhesion	HDA	21423176

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Z disc

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
structural constituent of muscle	IMP	19881492
actin filament binding	IDA	15823560
cell-cell adhesion mediator activity	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of muscle

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nexilin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
InterPro
Immunoglobulin I-set
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110326	hypertrophic cardiomyopathy 20	Alliance of Genome Resources
DOID:0110424	dilated cardiomyopathy 1CC	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	68810		MOUSE36640
Xenopus tropicalis	91624	Xenbase:XB-GENE-493147
Rattus norvegicus	246172		RATNO23716
Pan troglodytes	456967		PANTR21437
Bos taurus	504819		BOVIN26677
Danio rerio	573301		DANRE42003
Macaca mulatta	710960		MACMU25013
Monodelphis domestica	100031712		MONDO00047
Ornithorhynchus anatinus	100085152		ORNAN19616
Taeniopygia guttata	100232836		TAEGU29446

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements