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neurexin 1

Summary

Gene Symbol

NRXN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9378

PubChem

9378

Alliance of Genome Resources

HGNC:8008

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Angiogenesis
Calcium
Cell adhesion
Cell membrane
Cell projection
Disulfide bond
EGF-like domain
Glycoprotein
Heparan sulfate
Intellectual disability
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Schizophrenia
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 9** entries
UniProt	Protein Name
Q9ULB1	Neurexin I-alpha Neurexin-1-alpha
P58400	Neurexin I-beta
A0A1D5RMU6	Neurexin I-alpha Neurexin-1-alpha
E7ERL8	Neurexin I-alpha Neurexin-1-alpha
A0A0D9SEQ7
H0Y568
A0A0D9SEM5
E7EQN4
H7BYC7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 58 in total

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GO Term	Evidence Code	PMID
angiogenesis	ISS
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS
neuron cell-cell adhesion	ISS
neuron cell-cell adhesion	NAS	16242404
neuron cell-cell adhesion	TAS	15797875 18923512

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion [inference]

cell-cell adhesion [inference]

neuron cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

signal transduction

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

neuronal signal transduction

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar granule cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar granule cell differentiation

glutamatergic neuron differentiation [inference]

cerebellar granule cell differentiation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to cell junction [inference]

protein localization to synapse

gephyrin clustering involved in postsynaptic density assembly

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

protein-containing complex assembly [inference]

protein-containing complex assembly involved in synapse maturation

membrane assembly [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-containing complex assembly involved in synapse maturation

membrane organization [inference]

postsynaptic membrane organization [inference]

postsynaptic membrane assembly

membrane assembly [inference]

presynaptic membrane organization [inference]

presynaptic membrane assembly

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

learning or memory [inference]

learning

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

mechanosensory behavior [inference]

auditory behavior [inference]

vocal learning

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar granule cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar granule cell differentiation

glutamatergic neuron differentiation [inference]

cerebellar granule cell differentiation

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to cell junction [inference]

protein localization to synapse

gephyrin clustering involved in postsynaptic density assembly

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of protein localization

establishment of localization in cell [inference]

neurotransmitter secretion

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to cell junction [inference]

protein localization to synapse

gephyrin clustering involved in postsynaptic density assembly

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of neuromuscular synaptic transmission [inference]

positive regulation of neuromuscular synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of synapse maturation

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of synapse maturation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

regulation of cellular response to growth factor stimulus [inference]

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of synapse maturation

regulation of synapse maturation [inference]

positive regulation of synapse maturation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

neuronal signal transduction

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of neuromuscular synaptic transmission [inference]

positive regulation of neuromuscular synaptic transmission

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of presynapse assembly [inference]

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of synapse maturation

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of presynapse assembly [inference]

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

regulation of synapse maturation [inference]

positive regulation of synapse maturation

regulation of presynapse organization [inference]

regulation of presynapse assembly [inference]

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of synapse maturation

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of presynapse assembly [inference]

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of presynaptic active zone assembly [inference]

positive regulation of presynaptic active zone assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
nucleolus	IDA
endoplasmic reticulum	ISS
plasma membrane	ISS
plasma membrane	TAS
plasma membrane	IC	21424692

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-cell adhesion

trans-synaptic protein complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

cell projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

nucleolus

cell body [inference]

neuronal cell body

presynapse

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	ISS
signaling receptor binding	ISS
type 1 fibroblast growth factor receptor binding	IDA	22750515
calcium channel regulator activity	ISS
calcium ion binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

acetylcholine receptor binding

growth factor receptor binding [inference]

fibroblast growth factor receptor binding [inference]

type 1 fibroblast growth factor receptor binding

neuroligin family protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Neurexin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Laminin G domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111332	Pitt-Hopkins-like syndrome 2	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9369	FB:FBgn0038975
Xenopus tropicalis	9378	Xenbase:XB-GENE-952913
Drosophila melanogaster	9379	FB:FBgn0038975
Mus musculus	18189	Xenbase:XB-GENE-952913	MOUSE19959
Drosophila melanogaster	18191	FB:FBgn0038975
Rattus norvegicus	60391	Xenbase:XB-GENE-952913	RATNO35085
Drosophila melanogaster	116508	FB:FBgn0038975
Drosophila melanogaster	116595	FB:FBgn0038975
Pan troglodytes	459224		PANTR27596
Danio rerio	565531		DANRE04265

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements