GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Guidelines

MIRAGE

Rac/Cdc42 guanine nucleotide exchange factor 6

Summary

Gene Symbol

ARHGEF6

Organism

Homo sapiens (human)

External Links

NCBI Gene

9459

PubChem

9459

Alliance of Genome Resources

HGNC:685

JoGo

ARHGEF6

TogoVar

ARHGEF6

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Coiled coil
Guanine-nucleotide releasing factor
Phosphoprotein
Proteomics identification
Reference proteome
SH3 domain

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z3C7
Q15052	Alpha-Pix COOL-2 PAK-interacting exchange factor alpha Rac/Cdc42 guanine nucleotide exchange factor 6
Q8N4Q3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
apoptotic process	NAS	11564864
JNK cascade	NAS	11564864
lamellipodium assembly	ISS
lamellipodium assembly	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	TAS
cell-cell junction	IEA
lamellipodium	ISS
lamellipodium	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	NAS	11017088
guanyl-nucleotide exchange factor activity	TAS
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	NAS	9582122
protein binding	IPI	11864573 16374509 16983070 21295525 21900206 23455922 31980649 32296183 33961781 35271311

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rho guanine nucleotide exchange factor

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
lamellipodium assembly

Displaying **all 9** entries
InterPro
CH domain superfamily
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
PH-like domain superfamily
Pleckstrin homology domain
Rho guanine nucleotide exchange factor 6/7, coiled-coil domain
RhoGEF 6/7, PH domain
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1059	intellectual disability	Alliance of Genome Resources

About Release Notes Help Feedback

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: [email protected]

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026