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interleukin 27 receptor subunit alpha

Summary

Gene Symbol

IL27RA

Organism

Homo sapiens (human)

External Links

NCBI Gene

9466

PubChem

9466

Alliance of Genome Resources

HGNC:17290

JoGo

IL27RA

TogoVar

IL27RA

Annotation

Keyword

3D-structure
Glycoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6UWB1	Cytokine receptor WSX-1 Cytokine receptor-like 1 Type I T-cell cytokine receptor ZcytoR1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of T-helper 1 type immune response	IEA
negative regulation of type 2 immune response	IBA
immune response	TAS	9600072
cell surface receptor signaling pathway	TAS	9600072
cytokine-mediated signaling pathway

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

interleukin-27-mediated signaling pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

negative regulation of type 2 immune response

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of cellular extravasation [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

regulation of T cell extravasation [inference]

negative regulation of T cell extravasation

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of lymphocyte migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of T cell migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of T cell extravasation [inference]

negative regulation of T cell extravasation

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

regulation of immune effector process [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

regulation of leukocyte mediated immunity [inference]

regulation of lymphocyte mediated immunity [inference]

regulation of B cell mediated immunity [inference]

regulation of immunoglobulin mediated immune response [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

regulation of immunoglobulin mediated immune response [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 17 type immune response [inference]

negative regulation of T-helper 17 type immune response

regulation of type 2 immune response [inference]

negative regulation of type 2 immune response

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

negative regulation of type 2 immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

negative regulation of interleukin-17 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

negative regulation of interleukin-17 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

negative regulation of interleukin-17 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of cellular extravasation [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

regulation of T cell extravasation [inference]

negative regulation of T cell extravasation

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of lymphocyte migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of T cell migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of T cell extravasation [inference]

negative regulation of T cell extravasation

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

negative regulation of type 2 immune response

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

negative regulation of type 2 immune response

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

negative regulation of type 2 immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

regulation of immunoglobulin mediated immune response [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 17 type immune response [inference]

negative regulation of T-helper 17 type immune response

regulation of type 2 immune response [inference]

negative regulation of type 2 immune response

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 17 type immune response

negative regulation of type 2 immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

interleukin-27-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

negative regulation of interleukin-17 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of cellular extravasation [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

regulation of T cell extravasation [inference]

negative regulation of T cell extravasation

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of lymphocyte migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of T cell migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of T cell extravasation [inference]

negative regulation of T cell extravasation

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of T cell extravasation

negative regulation of mononuclear cell migration [inference]

negative regulation of lymphocyte migration [inference]

negative regulation of T cell migration [inference]

negative regulation of T cell extravasation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-17 production [inference]

negative regulation of interleukin-17 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

regulation of isotype switching [inference]

regulation of isotype switching to IgG isotypes

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type II interferon production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
external side of plasma membrane
receptor complex

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	TAS	9600072
protein binding	IPI	19386761 32296183
cytokine binding
interleukin-27 receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

cytokine receptor activity [inference]

interleukin-17 receptor activity [inference]

interleukin-27 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interleukin-17 receptor activity [inference]

interleukin-27 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interleukin-27 receptor subunit alpha

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
interleukin-27 receptor activity

Displaying **all 3** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements