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Standards Ontologies Notations
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

Summary
Gene Symbol
  • Hadha
Organism
Mus musculus (house mouse)
NCBI Gene
97212
PubChem
97212
Alliance of Genome Resources
Annotation
Keyword
  • Acetylation
  • Fatty acid metabolism
  • Lyase
  • Methylation
  • Mitochondrion inner membrane
  • Multifunctional enzyme
  • NAD
  • Oxidoreductase
  • Phosphoprotein
  • Reference proteome
  • Transferase
  • Transit peptide
Proteins
Displaying 1 entry
UniProt Protein Name
Q8BMS1
  • Monolysocardiolipin acyltransferase
  • TP-alpha
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 4 entries
GO Term Evidence Code PMID
cardiolipin acyl-chain remodeling
response to xenobiotic stimulus
response to insulin
fatty acid beta-oxidation
GO Hierarchy
Displaying entries 1 - 5 of 10 in total
GO Term Evidence Code PMID
protein binding
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
acetyl-CoA C-acyltransferase activity
NAD binding
enoyl-CoA hydratase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Rodentia
Group Name
trifunctional enzyme subunit alpha, mitochondrial
Functional Category
  • E: Amino acid transport and metabolism
  • G: Carbohydrate transport and metabolism
  • I: Lipid transport and metabolism
Displaying all 8 entries
Gene Ontology
3-hydroxyacyl-CoA dehydrogenase activity
NAD+ binding
catalytic activity
fatty acid beta-oxidation
fatty acid metabolic process
lyase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
Displaying all 9 entries
InterPro
3-hydroxyacyl-CoA dehydrogenase, C-terminal
3-hydroxyacyl-CoA dehydrogenase, NAD binding
3-hydroxyacyl-CoA dehydrogenase, conserved site
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
ClpP/crotonase-like domain superfamily
Enoyl-CoA hydratase/isomerase, conserved site
Enoyl-CoA hydratase/isomerase
Fatty acid oxidation complex, alpha subunit, mitochondrial
NAD(P)-binding domain superfamily
Disease
Disease Ontology
Displaying all 5 entries
DO ID Disease Name Source
DOID:0080208 metabolic dysfunction-associated steatotic liver disease
DOID:0111277 mitochondrial trifunctional protein deficiency
DOID:10652 Alzheimer's disease
DOID:3146 lipid metabolism disorder
DOID:9452 steatotic liver disease
Ortholog
Displaying entries 71 - 80 of 127 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
107550361 SINGR71047
107593272 SINGR55539
107600864 SINGR53770
108257474 ICTPU25963
108532679 RHIBE01226
109113066 CYPCA104772
109311569 CROPO09425
109685831 51338_0:00170d
110206510 PHACI17999
110294690 10089_0:0014d2
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024