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MIRAGE

hephaestin

Summary

Gene Symbol

HEPH

Organism

Homo sapiens (human)

External Links

NCBI Gene

9843

KEGG Gene ID

PubChem

9843

Alliance of Genome Resources

HGNC:4866

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Disulfide bond
Glycoprotein
Iron transport
Metal-binding
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Sodium
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
E7ES21	Cuproxidase ceruloplasmin Ferroxidase ceruloplasmin Glutathione peroxidase ceruloplasmin Glutathione-dependent peroxiredoxin ceruloplasmin
Q5JZ08
Q9BQS7
A0A0C4DG76
Q1HE23

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
iron ion transport
multicellular organismal-level iron ion homeostasis	ISS
multicellular organismal-level iron ion homeostasis	IEA
intestinal iron absorption	ISS
intestinal iron absorption	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal iron absorption

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of iron ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
obsolete extracellular space
plasma membrane	TAS
plasma membrane	IBA
basolateral plasma membrane	IDA
basolateral plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
ferroxidase activity	IDA
ferroxidase activity	IBA
ferroxidase activity	IEA
glutathione peroxidase activity	IEA
copper ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

glutathione peroxidase activity

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor [inference]

ferroxidase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

antioxidant activity [inference]

peroxidase activity [inference]

glutathione peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	15203	MGI:1332240
Rattus norvegicus	117240	RGD:71060

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026