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GlyCosmos Glycans

The list of validated glycans extracted from GlyTouCan, updated weekly.

Source	Last Updated
GlyTouCan	August 18, 2024

Displaying entries **6576 - 6600** of **9694** in total

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GlyTouCan ID	IUPAC Condensed	Motifs ▼	Subsumption Level	Monoisotopic Mass	Organisms
G88192MM	Neu5Ac(a2-3)[Gal(a1-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GM1 a-Gal antigen	Linkage defined saccharide	1160.4	Amphibia Anura Aquarana catesbeiana Aquarana Batrachia Bilateria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Eukaryota Eumetazoa Euteleostomi Gnathostomata Metazoa Neobatrachia Opisthokonta Rana Ranidae Ranoidea Sarcopterygii Teleostomi Tetrapoda Vertebrata cellular organisms
G86282JZ	Neu5Ac(a2-3)[Gal(a1-3)Gal(b1-3)Gal(a1-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GM1 a-Gal antigen	Linkage defined saccharide	1484.5	Amphibia Anura Batrachia Bilateria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Eukaryota Eumetazoa Euteleostomi Gnathostomata Metazoa Neobatrachia Opisthokonta Rana Ranidae Ranoidea Sarcopterygii Teleostomi Tetrapoda Vertebrata cellular organisms
G58452XH	Neu5Ac(a2-3)[Gal(b1-4)GlcNAc(b1-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GM1 N-acetyllactosamine Type 2 LN	Linkage defined saccharide	1363.48	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Myomorpha Opisthokonta Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G21570BS	Neu5Ac(a2-3)[Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GM1 Lewis x Lex N-acetyllactosamine SSEA-1 Type 2 LN	Linkage defined saccharide	1509.53	Amniota Archelosauria Archosauria Aves Bilateria Chordata Coelurosauria Craniata Deuterostomia Dinosauria Dipnotetrapodomorpha Eukaryota Eumetazoa Euteleostomi Galliformes Galloanserae Gallus gallus Gallus Gnathostomata Metazoa Neognathae Opisthokonta Phasianidae Phasianinae Sarcopterygii Sauria Saurischia Sauropsida Teleostomi Tetrapoda Theropoda Vertebrata cellular organisms
G13670FR	Neu5Ac(a2-3)[Gal(a1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GM1 I' antigen Type 2 LN2 a-Gal antigen	Linkage defined saccharide	1890.66	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Myomorpha Opisthokonta Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G32254QI	Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-	GL-7 globoseries ganglioside SSEA-4	Linkage defined saccharide	1160.4	Amniota Archelosauria Archosauria Aves Bilateria Boreoeutheria Catarrhini Chordata Coelurosauria Craniata Deuterostomia Dinosauria Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Galliformes Galloanserae Gallus gallus Gallus Glires Gnathostomata Haplorrhini Hominidae Homininae Hominoidea Homo sapiens Homo Mammalia Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Neognathae Opisthokonta Phasianidae Phasianinae Primates Rodentia Sarcopterygii Sauria Saurischia Sauropsida Simiiformes Teleostomi Tetrapoda Theria Theropoda Vertebrata cellular organisms
G70265CT	Neu5Ac(a2-3)[Neu5Ac(a2-6)]Gal(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-	GL-7 globoseries ganglioside SSEA-4	Linkage defined saccharide	1451.49	Amniota Archelosauria Archosauria Aves Bilateria Boreoeutheria Catarrhini Chordata Coelurosauria Craniata Deuterostomia Dinosauria Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Galliformes Galloanserae Gallus gallus Gallus Gnathostomata Haplorrhini Hominidae Homininae Hominoidea Homo sapiens Homo Mammalia Metazoa Neognathae Opisthokonta Phasianidae Phasianinae Primates Sarcopterygii Sauria Saurischia Sauropsida Simiiformes Teleostomi Tetrapoda Theria Theropoda Vertebrata cellular organisms
G08624VL	Neu5Ac9Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)[GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD2	Linkage defined saccharide	1460.49	Acanthomorphata Actinopteri Actinopterygii Bilateria Chordata Clupeocephala Craniata Ctenosquamata Deuterostomia Eukaryota Eumetazoa Eurypterygia Euteleosteomorpha Euteleostomi Gadariae Gadidae Gadiformes Gadoidei Gadus chalcogrammus Gadus Gnathostomata Metazoa Neopterygii Neoteleostei Opisthokonta Osteoglossocephalai Paracanthopterygii Pollachius pollachius Pollachius Teleostei Teleostomi Vertebrata Zeiogadaria cellular organisms
G02657AK	Neu5Ac(a2-8)Neu5Ac(a2-3)[GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD2	Linkage defined saccharide	1127.39	Acanthomorphata Actinopteri Actinopterygii African cichlids Amniota Amphibia Anura Archelosauria Archosauria Artiodactyla Aves Batrachia Bilateria Boreoeutheria Bos taurus Bos Bovidae Bovinae Canidae Caniformia Canis lupus familiaris Canis lupus Canis Carassius auratus Carassius Carnivora Catarrhini Cavia porcellus Cavia Caviidae Chordata Cichlidae Cichliformes Cichlomorphae Clupeocephala Coelurosauria Craniata Cricetidae Cricetinae Cricetulus griseus Cricetulus Ctenosquamata Cyprinidae Cypriniformes Cyprininae Cypriniphysae Cyprinoidei Cyprinus carpio Cyprinus Deuterostomia Dinosauria Dipnotetrapodomorpha Euacanthomorphacea Euarchontoglires Eukaryota Eumetazoa Eupercaria Eurypterygia Euteleosteomorpha Euteleostomi Eutheria Galliformes Galloanserae Gallus gallus Gallus Glires Gnathostomata Haplorrhini Hominidae Homininae Hominoidea Homo sapiens Homo Hystricomorpha Laurasiatheria Leuciscidae Leuciscinae Mammalia Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Neognathae Neopterygii Neoteleostei Nototheniidae Notothenioidei Opisthokonta Oreochromini Oreochromis mossambicus Oreochromis Ostariophysi Osteoglossocephalai Otomorpha Otophysi Ovalentaria Pecora Perciformes Percomorphaceae Phasianidae Phasianinae Pipidae Pipoidea Primates Pseudocrenilabrinae Rattus norvegicus Rattus Rodentia Ruminantia Sarcopterygii Sauria Saurischia Sauropsida Scardinius erythrophthalmus Scardinius Simiiformes Suidae Suina Sus scrofa Sus Teleostei Teleostomi Tetrapoda Theria Theropoda Trematomus lepidorhinus Trematomus Vertebrata Xenopodinae Xenopus cellular organisms
G37184KW	Neu5Ac(a2-8)Neu5Ac(a2-3)[Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1b	Linkage defined saccharide	1289.44	Acanthomorphata Actinopteri Actinopterygii African cichlids Amniota Amphibia Anura Archelosauria Archosauria Artiodactyla Aves Balaenoptera acutorostrata Balaenoptera brydei Balaenoptera edeni Balaenoptera Balaenopteridae Batoidea Batrachia Bilateria Boreoeutheria Bos taurus Bos Bovidae Bovinae Canidae Caniformia Canis lupus familiaris Canis lupus Canis Carassius auratus Carassius Carnivora Catarrhini Cercopithecidae Cercopithecinae Cercopithecoidea Cetacea Channichthyidae Chionodraco myersi Chionodraco Chondrichthyes Chordata Cichlidae Cichliformes Cichlomorphae Clupeocephala Coelurosauria Craniata Cricetidae Cricetinae Crocidurinae Ctenosquamata Cyprinidae Cypriniformes Cyprininae Cypriniphysae Cyprinoidei Cyprinus carpio Cyprinus Delphinidae Delphinus delphis Delphinus Deuterostomia Dinosauria Dipnotetrapodomorpha Discopyge tschudii Discopyge Elasmobranchii Euacanthomorphacea Euarchontoglires Eukaryota Eulipotyphla Eumetazoa Eupercaria Eurypterygia Euteleosteomorpha Euteleostomi Eutheria Felidae Feliformia Felinae Felis catus Felis Gadariae Gadidae Gadiformes Gadoidei Gadus morhua Gadus Galliformes Galloanserae Gallus gallus Gallus Glires Globicephala macrorhynchus Globicephala Gnathostomata Haplorrhini Hominidae Homininae Hominoidea Homo sapiens Homo Lagomorpha Laurasiatheria Leporidae Leuciscidae Leuciscinae Leucoraja erinacea Leucoraja Mammalia Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Mysticeti Narcinidae Neognathae Neopterygii Neoteleostei Nototheniidae Notothenioidei Odontoceti Opisthokonta Orcinus orca Orcinus Oreochromini Oreochromis mossambicus Oreochromis Oryctolagus cuniculus Oryctolagus Ostariophysi Osteoglossocephalai Otomorpha Otophysi Ovalentaria Papio hamadryas Papio Paracanthopterygii Pecora Perciformes Percomorphaceae Phasianidae Phasianinae Phocoenidae Phocoenoides dalli Phocoenoides Phodopus sungorus Phodopus Physeter catodon Physeter Physeteridae Pipidae Pipoidea Primates Pseudocrenilabrinae Rajidae Rajiformes Rattus Rodentia Ruminantia Sarcopterygii Sauria Saurischia Sauropsida Scardinius erythrophthalmus Scardinius Simiiformes Soricidae Stenella coeruleoalba Stenella Suidae Suina Suncus murinus Suncus Sus scrofa Sus Teleostei Teleostomi Tetrapoda Theria Theropoda Torpedinidae Torpediniformes Torpedo marmorata Torpedo Trematomus lepidorhinus Trematomus Tursiops truncatus Tursiops Vertebrata Whippomorpha Xenopodinae Xenopus laevis Xenopus Xenopus Zeiogadaria cellular organisms
G50531HE	Neu5Ac(a2-8)Neu5Ac(a2-3)[Neu5Ac(a2-8)Neu5Ac9Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1b	Linkage defined saccharide	1913.64	Amniota Archelosauria Archosauria Aves Bilateria Chordata Coelurosauria Craniata Deuterostomia Dinosauria Dipnotetrapodomorpha Eukaryota Eumetazoa Euteleostomi Galliformes Galloanserae Gallus gallus Gallus Gnathostomata Metazoa Neognathae Opisthokonta Phasianidae Phasianinae Sarcopterygii Sauria Saurischia Sauropsida Teleostomi Tetrapoda Theropoda Vertebrata cellular organisms
G94976BB	Neu5Ac(a2-8)Neu5Ac(a2-3)[Neu5Gc(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1b	Linkage defined saccharide	1596.53	Amniota Artiodactyla Bilateria Boreoeutheria Bos taurus Bos Bovidae Bovinae Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Lagomorpha Laurasiatheria Leporidae Mammalia Metazoa Opisthokonta Oryctolagus cuniculus Oryctolagus Pecora Ruminantia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G03739GM	Neu5Ac(a2-8)Neu5Ac(a2-3)[Gal(a1-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1b a-Gal antigen	Linkage defined saccharide	1451.49	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Myomorpha Opisthokonta Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G34993RG	Neu5Ac(a2-8)Neu5Ac(a2-3)[Gal(a1-3)Gal(a1-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1b a-Gal antigen	Linkage defined saccharide	1613.54	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Myomorpha Opisthokonta Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G46677TE	Neu5Ac(a2-3)[Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1a	Linkage defined saccharide	1289.44	Acanthomorphata Actinopteri Actinopterygii Amniota Archelosauria Archosauria Artiodactyla Aves Bilateria Boreoeutheria Bos taurus Bos Bovidae Bovinae Carangaria Carassius auratus Carassius Carnivora Catarrhini Cercopithecidae Cercopithecinae Cercopithecoidea Cetacea Chinchillidae Chordata Cichlidae Cichliformes Cichlomorphae Clupeocephala Coelurosauria Craniata Cricetidae Cricetinae Cricetulus griseus Cricetulus Ctenosquamata Cyprinidae Cypriniformes Cyprininae Cypriniphysae Cyprinoidei Delphinidae Deuterostomia Dinosauria Dipnotetrapodomorpha Discoba Euacanthomorphacea Euarchontoglires Euglenozoa Eukaryota Eulipotyphla Eumetazoa Eurypterygia Euteleosteomorpha Euteleostomi Eutheria Felidae Feliformia Felinae Felis catus Felis Galliformes Galloanserae Gallus gallus Gallus Glires Gnathostomata Haplorrhini Hominidae Homininae Hominoidea Homo sapiens Homo Hystricomorpha Kinetoplastea Lagomorpha Laurasiatheria Leishmania amazonensis Leishmania mexicana species complex Leishmania Leishmania Leishmaniinae Leporidae Mammalia Meleagridinae Meleagris gallopavo Meleagris Metakinetoplastina Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Neognathae Neopterygii Neoteleostei Odontoceti Oncorhynchus mykiss Oncorhynchus Opisthokonta Oryctolagus cuniculus Oryctolagus Ostariophysi Osteoglossocephalai Otomorpha Otophysi Ovalentaria Papio hamadryas Papio Parophrys vetulus Parophrys Pecora Percomorphaceae Phasianidae Phasianinae Pleuronectidae Pleuronectiformes Pleuronectoidei Primates Protacanthopterygii Rattus Rodentia Ruminantia Salmonidae Salmoniformes Salmoninae Sarcopterygii Sauria Saurischia Sauropsida Simiiformes Soricidae Suidae Suina Sus scrofa Sus Teleostei Teleostomi Tetrapoda Theria Theropoda Trypanosomatida Trypanosomatidae Tursiops truncatus Tursiops Vertebrata Whippomorpha cellular organisms
G46774NB	Neu5Ac9Ac(a2-8)Neu5Ac(a2-3)[Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1a	Linkage defined saccharide	1622.55	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Opisthokonta Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G53446FI	Neu9Ac(a2-8)Neu5Ac(a2-3)[Neu9Ac(a2-8)Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1a	Linkage defined saccharide	1871.63	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Myomorpha Opisthokonta Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G56268BR	Neu5Ac9Ac(a2-8)Neu5Ac(a2-3)[Neu5Ac9Ac(a2-8)Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1a	Linkage defined saccharide	1955.65	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Myomorpha Opisthokonta Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G92175CL	Neu5Ac(a2-3)[Neu5Ac(a2-3)[GalNAc(b1-4)]Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1a	Linkage defined saccharide	1492.52	Amniota Bilateria Boreoeutheria Caniformia Carnivora Catarrhini Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Gnathostomata Haplorrhini Hominidae Homininae Hominoidea Homo sapiens Homo Laurasiatheria Mammalia Metazoa Opisthokonta Otariidae Pinnipedia Primates Sarcopterygii Simiiformes Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G89393WA	Neu5Ac(a2-3)[GalNAc(b1-?)[Neu5Ac(a2-3)]Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1a	Linkage defined saccharide	1492.52	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Opisthokonta Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G45714BQ	Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)]GalNAc(b1-4)Gal(b1-4)Glc(b1-	GD1a	Linkage defined saccharide	1289.44	Amniota Amphibia Anura Batrachia Bilateria Boreoeutheria Catarrhini Chondrichthyes Chordata Craniata Deuterostomia Dipnotetrapodomorpha Elasmobranchii Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Haplorrhini Hominidae Homininae Hominoidea Homo sapiens Homo Mammalia Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Neobatrachia Opisthokonta Primates Rana Ranidae Ranoidea Rattus Rodentia Sarcopterygii Selachii Simiiformes Squalidae Squaliformes Squalomorphii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G81983KG	Neu5Ac(a2-8)Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-	GD1 GD1c	Linkage defined saccharide	1289.44	Amniota Bilateria Boreoeutheria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Euarchontoglires Eukaryota Eumetazoa Euteleostomi Eutheria Glires Gnathostomata Mammalia Metazoa Muridae Murinae Muroidea Mus musculus Mus Mus Myomorpha Opisthokonta Rattus norvegicus Rattus Rodentia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G84439WZ	Neu5Ac(a2-8)Neu5Gc(a2-3)[Neu5Ac(a2-8)Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-	GD1 GD1c N-Glycolyl-GM2	Linkage defined saccharide	1887.62	Amniota Artiodactyla Bilateria Boreoeutheria Bos taurus Bos Bovidae Bovinae Chordata Craniata Deuterostomia Dipnotetrapodomorpha Eukaryota Eumetazoa Euteleostomi Eutheria Gnathostomata Laurasiatheria Mammalia Metazoa Opisthokonta Pecora Ruminantia Sarcopterygii Teleostomi Tetrapoda Theria Vertebrata cellular organisms
G14767HC	Neu5Ac(a2-8)Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-8)Neu5Ac(a2-6)]GalNAc(b1-4)Gal(b1-4)Glc(b1-	GD1 GD1a GD1c	Linkage defined saccharide	1871.63	Amphibia Anura Batrachia Bilateria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Eukaryota Eumetazoa Euteleostomi Gnathostomata Metazoa Neobatrachia Opisthokonta Rana Ranidae Ranoidea Sarcopterygii Teleostomi Tetrapoda Vertebrata cellular organisms
G96991NM	Neu5Ac(a2-8)Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)]GalNAc(b1-4)Gal(b1-4)Glc(b1-	GD1 GD1a GD1c	Linkage defined saccharide	1580.53	Amphibia Anura Batrachia Bilateria Chordata Craniata Deuterostomia Dipnotetrapodomorpha Eukaryota Eumetazoa Euteleostomi Gnathostomata Metazoa Neobatrachia Opisthokonta Rana Ranidae Ranoidea Sarcopterygii Teleostomi Tetrapoda Vertebrata cellular organisms