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G02657AK

Summary

GlyTouCan ID: G02657AK
IUPAC Condensed: Neu5Ac(a2-8)Neu5Ac(a2-3)[GalNAc(b1-4)]Gal(b1-4)Glc(b1-
Motifs: GD2
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 1127.39

External Links

GlyGen

G02657AK

ChEBI

59218

PubChem Compound

45266844

PubChem Substance

252280026

3D Structures

GLYCAM: Neup5Aca2-8Neup5Aca2-3[DGalpNAcb1-4]DGalpb1-4DGlcpb1-OH

GlycoShape

G02657AK

Displaying 1 entry
Archetype	α	β
G98397EB	G78945LF	G02657AK

Organisms

Displaying entries **1 - 5** of 19 in total

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Organisms	Evidence
Gallus gallus (chicken)	GlyTouCan(glycome-db)
Cricetinae (hamsters)	GlyTouCan(glycome-db)
Scardinius erythrophthalmus (rudd)	GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyTouCan(glycome-db)
Cavia porcellus (domestic guinea pig)	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

cellular organisms [inference]

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates)

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Rattus

Rattus norvegicus (Norway rat)

Cricetidae [inference]

Cricetinae (hamsters)

Cricetulus [inference]

Cricetulus griseus (Chinese hamster)

Hystricomorpha (guinea pigs and others) [inference]

Caviidae (cavies) [inference]

Cavia (guinea pigs) [inference]

Cavia porcellus (domestic guinea pig)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Laurasiatheria [inference]

Carnivora (carnivores) [inference]

Caniformia [inference]

Canidae (dog, coyote, wolf, fox) [inference]

Canis [inference]

Canis lupus (gray wolf) [inference]

Canis lupus familiaris (dog)

Artiodactyla (even-toed ungulates & whales) [inference]

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Sauropsida (sauropsids) [inference]

Sauria (diapsids) [inference]

Archelosauria [inference]

Archosauria [inference]

Dinosauria [inference]

Saurischia [inference]

Theropoda [inference]

Coelurosauria [inference]

Aves (birds) [inference]

Neognathae [inference]

Galloanserae [inference]

Galliformes (landfowls) [inference]

Phasianidae (turkeys) [inference]

Phasianinae [inference]

Gallus [inference]

Gallus gallus (chicken)

Amphibia (amphibians) [inference]

Batrachia [inference]

Anura (frogs and toads) [inference]

Pipoidea [inference]

Pipidae (tongueless frogs) [inference]

Xenopodinae [inference]

Xenopus

Actinopterygii (ray-finned fishes) [inference]

Actinopteri [inference]

Neopterygii [inference]

Teleostei (teleost fishes) [inference]

Osteoglossocephalai [inference]

Clupeocephala [inference]

Otomorpha [inference]

Ostariophysi [inference]

Otophysi [inference]

Cypriniphysae [inference]

Cypriniformes (carps and others) [inference]

Cyprinoidei [inference]

Cyprinidae [inference]

Cyprininae [inference]

Carassius [inference]

Carassius auratus (goldfish)

Cyprinus [inference]

Cyprinus carpio (common carp)

Leuciscidae [inference]

Leuciscinae [inference]

Scardinius [inference]

Scardinius erythrophthalmus (rudd)

Euteleosteomorpha [inference]

Neoteleostei [inference]

Eurypterygia [inference]

Ctenosquamata [inference]

Acanthomorphata [inference]

Euacanthomorphacea [inference]

Percomorphaceae [inference]

Eupercaria [inference]

Perciformes (perches and others) [inference]

Notothenioidei [inference]

Nototheniidae (Antarctic cods) [inference]

Trematomus [inference]

Trematomus lepidorhinus (slender scalyhead)

Ovalentaria [inference]

Cichlomorphae [inference]

Cichliformes (cichlids and convict blennies) [inference]

Cichlidae (cichlids)

African cichlids [inference]

Pseudocrenilabrinae [inference]

Oreochromini [inference]

Oreochromis [inference]

Oreochromis mossambicus (Mozambique tilapia)

GlycoGene Database (GGDB)

Displaying 1 entry
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
B4GALNT1	UDP-GalNAc	G98544DH	Cer	G02657AK	Cer	1601877 7890749

KEGG BRITE Database

KEGG ID

G00114

Enzyme

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05948	2.4.1.62	G02657AK	G37184KW
R05946	2.4.1.92	G98544DH	G02657AK

GlycoEpitope

Epitope ID: EP0061

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
4s:n-acetyl
5b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
6s:n-acetyl
7b:b-dgal-HEX-1:5
8s:n-acetyl
LIN
1:1o(4+1)2d
2:2o(3+2)3d
3:3d(5+1)4n
4:3o(8+2)5d
5:5d(5+1)6n
6:2o(4+1)7d
7:7d(2+1)8n

WURCS

WURCS=2.0/4,5,4/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O][a2112h-1b_1-5_2*NCC/3=O]/1-2-3-3-4/a4-b1_b3-c2_b4-e1_c8-d2

Literature

Displaying entries **1 - 10** of 28 in total

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PubMed ID	Title	First Author	Publication Date	Source
26179345	Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody	Horwacik I	2015 Oct	PubChem
16895906	Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b	Attrill H	2006 Oct 27	PubChem
15464996	Gangliosides of organ-confined versus metastatic androgen-receptor-negative prostate cancer	Ravindranath MH	2004 Nov 05	GlyGen GlycoEpitope
9456440	Induction of IgG antibodies by an anti-idiotype antibody mimicking disialoganglioside GD2	Sen G	1998 Jan	GlyGen GlycoEpitope
9317004	Serum antibodies against gangliosides and Campylobacter jejuni lipopolysaccharides in Miller Fisher syndrome	Neisser A	1997 Oct	PubChem
9516847	Detection of neuroblastoma cells in CD34+ selected peripheral stem cells using a combination of tyrosine hydroxylase nested RT-PCR and anti-ganglioside GD2 immunocytochemistry	Lode HN	1997 Oct	GlyGen GlycoEpitope
9815586	Preclinical evaluation in nonhuman primates of murine monoclonal anti-idiotype antibody that mimics the disialoganglioside GD2	Sen G	1997 Nov	GlyGen GlycoEpitope
9406719	Preclinical analysis of radiolabeled anti-GD2 immunoglobulin G	Vriesendorp FJ	1997 Dec 15	GlyGen GlycoEpitope
9171318	Pathogenesis of the neurotoxicity caused by anti-GD2 antibody therapy	Yuki N	1997 Aug	GlyGen GlycoEpitope
8891271	Immunocytochemical analysis of gangliosides in rat primary cerebellar cultures using specific monoclonal antibodies	Kawashima I	1996 Sep 02	GlyGen GlycoEpitope

PubAnnotation

Displaying entries **1 - 5** of 10 in total

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Title	Authors	Source	Publication Date	PubMed ID
Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells.	Giraudo CG Maccioni HJ	J Biol Chem	2003 Oct 10	12900410
Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals.	Mitsuda T Furukawa K Fukumoto S Miyazaki H Urano T Furukawa K	J Biol Chem	2002 Mar 29	11782461
Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides.	Miljan EA Meuillet EJ Mania-Farnell B George D Yamamoto H Simon HG Bremer EG	J Biol Chem	2002 Mar 22	11796728
Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides.	Furukawa K Takamiya K Furukawa K	Biochim Biophys Acta	2002 Dec 19	12417418
Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside.	Inoue M Fujii Y Furukawa K Okada M Okumura K Hayakawa T Furukawa K Sugiura Y	J Biol Chem	2002 Aug 16	12023957

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

KEGG BRITE Database

GlycoEpitope

Sequence Descriptors

International Collaboration

Acknowledgements