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MIRAGE
Tumor necrosis factor receptor superfamily member 10A
Summary
- UniProt ID
- O00220
- Gene Symbol
-
- APO2
- DR4
- TNFRSF10A
- TRAILR1
- Gene ID
- 8797
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Apoptosis
- Cell membrane
- Cytoplasm
- Disulfide bond
- Glycoprotein
- Methylation
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| Golgi apparatus |
| cytosol |
| cell surface |
| plasma membrane raft |
| membrane raft |
| GO Term |
|---|
| death receptor activity |
| TRAIL binding |
| signaling receptor activity |
| protease binding |
| identical protein binding |
Sequence
MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 33 |
|
|
||
| 113 |
|
|||
| 117 |
|
|||
| 120 |
|
|||
| 126 |
|
|||
| 156 | N-linked (GlcNAc...) asparagine |
|
||
| 159 |
|
|
||
| 160 |
|
|
||
| 422 |
|
|||
| 424 |
|
G57321FI
G43417UB
G83460ZZ
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CASP8 activity is inhibited | Homo sapiens |
| Cell surface interactions at the vascular wall | Homo sapiens |
| Dimerization of procaspase-8 | Homo sapiens |
| Ligand-dependent caspase activation | Homo sapiens |
| RIPK1-mediated regulated necrosis | Homo sapiens |
| Regulation by c-FLIP | Homo sapiens |
| TP53 Regulates Transcription of Death Receptors and Ligands | Homo sapiens |
| TRAIL signaling | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050746 | mantle cell lymphoma | |
| DOID:11054 | urinary bladder cancer | |
| DOID:4362 | cervical cancer | |
| DOID:4450 | renal cell carcinoma | |
| DOID:4914 | esophagus adenocarcinoma | |
| DOID:5520 | head and neck squamous cell carcinoma | |
| DOID:9538 | multiple myeloma |
