GlyCosmos Portal

Submissions

TP53 Regulates Transcription of Death Receptors and Ligands

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6803211

PubChem

R-HSA-6803211

Description

Pro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). TRAIL receptors and FAS induce pro-apoptotic signaling in response to external stimuli via extrinsic apoptosis pathway (Wu et al. 1997, Takimoto et al. 2000, Guan et al. 2001, Liu et al. 2004, Ruiz de Almodovar et al. 2004, Liu et al. 2005, Schilling et al. 2009, Wilson et al. 2013). IGFBP3 is a transcriptional target of TP53 that may serve as a ligand for a novel death receptor TMEM219 (Buckbinder et al. 1995, Ingermann et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00220	Tumor necrosis factor receptor superfamily member 10A	APO2 DR4 TNFRSF10A TRAILR1	view
O14763	Tumor necrosis factor receptor superfamily member 10B	DR5 KILLER TNFRSF10B TRAILR2 TRICK2 UNQ160/PRO186 ZTNFR9	view
O14798	Tumor necrosis factor receptor superfamily member 10C	DCR1 LIT TNFRSF10C TRAILR3 TRID UNQ321/PRO366	view
P04637	Cellular tumor antigen p53	P53 TP53	view
P17936	Insulin-like growth factor-binding protein 3	IBP3 IGFBP3	view
P25445	Tumor necrosis factor receptor superfamily member 6	APT1 FAS FAS1 TNFRSF6	view
Q13625	Apoptosis-stimulating of p53 protein 2	ASPP2 BBP TP53BP2	view
Q86XT9	Insulin-like growth factor-binding protein 3 receptor	TMEM219	view
Q9UBN6	Tumor necrosis factor receptor superfamily member 10D	DCR2 TNFRSF10D TRAILR4 TRUNDD UNQ251/PRO288	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback