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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
GDNF family receptor alpha-2
Summary
- UniProt ID
- O00451
- Gene Symbol
-
- GFRA2
- GDNFRB
- RETL2
- TRNR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disulfide bond
- GPI-anchor
- Receptor
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| receptor complex |
| extrinsic component of membrane |
| external side of plasma membrane |
| GO Term |
|---|
| heparan sulfate binding |
| glial cell-derived neurotrophic factor receptor activity |
Sequence
MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 52 | N-linked (GlcNAc...) asparagine |
|
||
| 357 | N-linked (GlcNAc...) asparagine | |||
| 367 |
|
|||
| 396 |
|
|||
| 401 |
|
|||
| 413 | N-linked (GlcNAc...) asparagine |
|
G27058EU
G73430PD
G57321FI
G57317CE
G53434XO
G43417UB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| NCAM1 interactions | Homo sapiens |
| RAF/MAP kinase cascade | Homo sapiens |
| RET signaling | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060672 | Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:10487 | Hirschsprung's disease | |
| DOID:13548 | secondary Parkinson disease | |
| DOID:1389 | polyneuropathy | |
| DOID:162 | cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:2006 | preretinal fibrosis | |
| DOID:299 | adenocarcinoma | |
| DOID:3172 | papillary adenoma |
