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MIRAGE
RET signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
GFRA1,GFRA3RET:GFRA1,GFRA3RETGFRA1, GFRA2RET:GFRA1,GFRA2GFRA4RET:GFRA4RET:GFRA1,GFRA2:GDNF,NRTNGDNF,NRTNARTNRET:GFRA1,GFRA3:ARTNRET:GFRA4:PSPNPSPNRET:GFRA:GDNF complexes2x RET:GFRA:GDNF complexesATP2x p-5Y-RET:GDNF:GFRA complexesADP2x p-S696-RET:GFRA:GDNF complexesDOK1,DOK2,DOK4,DOK5,DOK62x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK62x p-5Y-RET:GDNF:GFRA complexes:RET interactorsRET interactorsFRS22x p-5Y-RET:GDNF:GFRA complexes:FRS22x p-5Y-RET:GDNF:GFRA complexes:SHC1SHC2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC12x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1GRB2-1:SOS12x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1p-5Y-RET:GDNF:GFRA complexes with and without p-SHC12x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1Ash-LGAB1,GAB22x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB22x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB22x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ksp85-containing Class 1A PI3Ks2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11SHP2GRB7,GRB102x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB102x p-5Y-RET:GDNF:GFRA complexes:PLCG1PLC12x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAPSRC-1, RAP1GAP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025