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Cyclin-dependent kinase inhibitor 1B
Summary
- UniProt ID
- O08769
- Gene Symbol
-
- Cdkn1b
- p27Kip1
- Gene ID
- 83571
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cytoplasm
- Endosome
- Nucleus
- Phosphoprotein
- Protein kinase inhibitor
- Proteomics identification
- Reference proteome
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| protein-containing complex |
| nucleoplasm |
| endosome |
| cytosol |
| Cul4A-RING E3 ubiquitin ligase complex |
Sequence
MSNVRVSNGSPSLERMDARQTEHPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGRYEWQEVERGSLPEFYYRPPRPPKSACKVPAQESLDVSGSRQAVPSIGSQANSEDRHLVDQMPDSSDSPAGLAEQCPGMRKRPAAEDSSSQNKRANRTEENVSDGSPNAGTVEQTPKKPGLRRQT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 2 |
|
|||
| 110 |
|
|||
| 197 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Rattus norvegicus |
| Cyclin A:Cdk2-associated events at S phase entry | Rattus norvegicus |
| Cyclin D associated events in G1 | Rattus norvegicus |
| Cyclin E associated events during G1/S transition | Rattus norvegicus |
| DNA Damage/Telomere Stress Induced Senescence | Rattus norvegicus |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | Rattus norvegicus |
| PTK6 Regulates Cell Cycle | Rattus norvegicus |
| SCF(Skp2)-mediated degradation of p27/p21 | Rattus norvegicus |
| Senescence-Associated Secretory Phenotype (SASP) | Rattus norvegicus |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050771 | pheochromocytoma | |
| DOID:0050773 | paraganglioma | |
| DOID:3125 | multiple endocrine neoplasia | |
| DOID:3829 | pituitary adenoma | |
| DOID:5223 | infertility | |
| DOID:5844 | myocardial infarction | |
| DOID:83 | cataract |
