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Telomerase reverse transcriptase

Summary

UniProt ID

O14746

Gene Symbol

TERT
EST2
TCS1
TRT

Organism

Homo sapiens (human)

External Links

GlyGen: O14746
PubChem: O14746
The Human Metabolome Database: HMDBP02739
The O-GlcNAc Database: O14746

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA-binding
Disease variant
Dyskeratosis congenita
Magnesium
Metal-binding
Nucleus
Phosphoprotein
RNA-directed DNA polymerase
Reference proteome
Ribonucleoprotein
Telomere
Ubl conjugation

Gene Ontology (GO)

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GO Term
mitochondrion organization
positive regulation of glucose import
telomere maintenance
RNA-templated transcription
RNA-templated DNA biosynthetic process
telomere maintenance via telomerase
DNA strand elongation
siRNA processing
positive regulation of G1/S transition of mitotic cell cycle
establishment of protein localization to telomere

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GO Term
nucleolus
plasma membrane
TERT-RMRP complex
PML body
nuclear speck
RNA-directed RNA polymerase complex
chromosome, telomeric region
cytosol
mitochondrial nucleoid
telomerase catalytic core complex

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GO Term
DNA binding
RNA binding
metal ion binding
protein-folding chaperone binding
identical protein binding
protein homodimerization activity
tRNA binding
transcription coactivator binding
telomerase activity
telomerase RNA reverse transcriptase activity

Annotation information from UniProt.

Sequence

MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Formation of the beta-catenin:TCF transactivating complex	Homo sapiens
Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence	Homo sapiens
Telomere Extension By Telomerase	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements