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Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9825895

PubChem

R-HSA-9825895

Description

MITF target genes are involved in DNA replication, damage repair and chromosome maintenance and stability (Strub et al, 2011; Giuliano et al, 2010; Seoane et al, 2019; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019). Cells depleted of MITF through siRNA can undergo senescence as a result of accumulating DNA damage. In contrast, cells that are depleted of MITF by overexpression of ATF4 undergo reversible cell cycle arrest but do not undergo senescence, suggesting that ATF4 and translational reprogramming may block the senescence pathway (Giuliano et al, 2010; Falletta et al, 2017; reviewed in Goding and Arnheiter, 2019).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14746	Telomerase reverse transcriptase	EST2 TCS1 TERT TRT	view
P18858	DNA ligase 1	LIG1	view
P38398	Breast cancer type 1 susceptibility protein	BRCA1 RNF53	view
P49736	DNA replication licensing factor MCM2	BM28 CCNL1 CDCL1 KIAA0030 MCM2	view

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