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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Proepiregulin
Summary
- UniProt ID
- O14944
- Gene Symbol
-
- EREG
- Organism
- Homo sapiens (human)
External Links
- PubChem
- O14944
Annotation
- Keyword
-
- 3D-structure
- Angiogenesis
- Cell membrane
- Developmental protein
- Differentiation
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Growth factor
- Mitogen
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| keratinocyte differentiation |
| wound healing |
| positive regulation of phosphorylation |
| positive regulation of innate immune response |
| negative regulation of epithelial cell proliferation |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| clathrin-coated endocytic vesicle membrane |
Sequence
MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 47 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Homo sapiens |
| Clathrin-mediated endocytosis | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Downregulation of ERBB2 signaling | Homo sapiens |
| EGFR downregulation | Homo sapiens |
| EGFR interacts with phospholipase C-gamma | Homo sapiens |
| ERBB2 Activates PTK6 Signaling | Homo sapiens |
| ERBB2 Regulates Cell Motility | Homo sapiens |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | Homo sapiens |
| Extra-nuclear estrogen signaling | Homo sapiens |
