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ERBB2 Activates PTK6 Signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8847993

PubChem

R-HSA-8847993

Description

PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). However, it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2, since it is known that ERBB2 forms heterodimers with EGFR (Spivak-Kroizman et al. 1992), and MET can heterodimerize with both EGFR and ERBB2 (Tanizaki et al. 2011).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14511	Pro-neuregulin-2, membrane-bound isoform	NRG2 NTAK	view
O14944	Proepiregulin	EREG	view
P00533	Epidermal growth factor receptor	EGFR ERBB ERBB1 HER1	view
P01133	Pro-epidermal growth factor	EGF	view
P04626	Receptor tyrosine-protein kinase erbB-2	ERBB2 HER2 MLN19 NEU NGL	view
P35070	Probetacellulin	BTC	view
P56975	Pro-neuregulin-3, membrane-bound isoform	NRG3	view
Q02297	Pro-neuregulin-1, membrane-bound isoform	GGF HGL HRGA NDF NRG1 SMDF	view
Q8WWG1	Pro-neuregulin-4, membrane-bound isoform	NRG4	view
Q99075	Proheparin-binding EGF-like growth factor	DTR DTS HBEGF HEGFL	view

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