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MIRAGE
Pro-epidermal growth factor

Summary
UniProt ID
P01133
Gene Symbol
  • EGF
Gene ID
1950
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P01133
PubChem
P01133
The Human Metabolome Database
HMDBP02438
The O-GlcNAc Database
P01133
Re-Glyco
P01133
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Growth factor
  • Primary hypomagnesemia
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 7 entries
GO Term
platelet alpha granule lumen
clathrin-coated endocytic vesicle membrane
extracellular region
extracellular space
plasma membrane
lysosomal membrane
extracellular exosome
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 14 in total
Position Description PubMed ID GlyTouCan ID Source
38 N-linked (GlcNAc...) asparagine
104 N-linked (GlcNAc...) asparagine
117 N-linked (GlcNAc...) asparagine
148 N-linked (GlcNAc...) asparagine
324 N-linked (GlcNAc...) asparagine
404 N-linked (GlcNAc...) asparagine
596 N-linked (GlcNAc...) asparagine
801
807
815 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 33 in total
Pathway Name Organism
Cargo recognition for clathrin-mediated endocytosis Homo sapiens
Clathrin-mediated endocytosis Homo sapiens
Constitutive Signaling by Aberrant PI3K in Cancer Homo sapiens
Constitutive Signaling by EGFRvIII Homo sapiens
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Homo sapiens
Differentiation of keratinocytes in interfollicular epidermis in mammalian skin Homo sapiens
Downregulation of ERBB2 signaling Homo sapiens
EGFR downregulation Homo sapiens
EGFR interacts with phospholipase C-gamma Homo sapiens
ERBB2 Activates PTK6 Signaling Homo sapiens
Disease
Displaying entries 1 - 10 of 11 in total
DO ID Disease Name Source
DOID:0050782 Zollinger-Ellison syndrome
DOID:0060879 primary hypomagnesemia
DOID:0060882 renal hypomagnesemia 4
DOID:1380 endometrial cancer
DOID:3068 glioblastoma
DOID:3070 high grade glioma
DOID:3121 gallbladder cancer
DOID:3181 oligodendroglioma
DOID:3908 lung non-small cell carcinoma
DOID:3910 lung adenocarcinoma
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025