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Proheparin-binding EGF-like growth factor

Summary

UniProt ID

Q99075

Gene Symbol

HBEGF
DTR
DTS
HEGFL

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

Q99075

PubChem

Q99075

The Human Metabolome Database

HMDBP02701

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Heparin-binding
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
epidermal growth factor receptor signaling pathway
signal transduction
muscle organ development
regulation of heart contraction
positive regulation of cell population proliferation
positive regulation of cell migration
positive regulation of cell growth
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of keratinocyte migration

Displaying **all 6** entries
GO Term
plasma membrane
endocytic vesicle membrane
clathrin-coated endocytic vesicle membrane
cell surface
extracellular region
extracellular space

Displaying **all 5** entries
GO Term
heparin binding
transmembrane receptor protein tyrosine kinase activator activity
receptor ligand activity
epidermal growth factor receptor binding
growth factor activity

Annotation information from UniProt.

Sequence

MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
32			G57321FI	GlyGen
37	O-linked (GalNAc...) threonine	23234360	G53434XO	UniProt GlyGen
38	O-linked (GalNAc...) serine	23234360		UniProt GlyGen
44	O-linked (GalNAc...) threonine	22171320 23234360	G48584BU G53434XO G29931IJ G43417UB	UniProt GlyGen GlyConnect
46			G50757KG	GlyGen GlyConnect
47	O-linked (GalNAc...) threonine	22171320	G81006GJ G53434XO G43417UB	UniProt GlyGen GlyConnect
74			G57321FI	GlyGen
75	O-linked (GalNAc...) threonine	1556128	G57321FI	UniProt GlyGen
77			G57321FI	GlyGen
78			G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Cargo recognition for clathrin-mediated endocytosis	Homo sapiens
Clathrin-mediated endocytosis	Homo sapiens
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
Downregulation of ERBB2 signaling	Homo sapiens
EGFR Transactivation by Gastrin	Homo sapiens
EGFR downregulation	Homo sapiens
EGFR interacts with phospholipase C-gamma	Homo sapiens
ERBB2 Activates PTK6 Signaling	Homo sapiens
ERBB2 Regulates Cell Motility	Homo sapiens
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Homo sapiens