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Glutamate receptor ionotropic, NMDA 2D

Summary

UniProt ID: O15399
Gene Symbol: GRIN2D GluN2D NMDAR2D
Gene ID: 2906
Organism: Homo sapiens (human)

External Links

GlyGen: O15399
PubChem: O15399
The Human Metabolome Database: HMDBP01645
Re-Glyco: O15399

Annotation

Keyword: 3D-structure Calcium Cell membrane Disease variant Disulfide bond Epilepsy Glycoprotein Ligand-gated ion channel Magnesium Methylation Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
startle response
brain development	NAS	PMID
adult locomotory behavior
ionotropic glutamate receptor signaling pathway	NAS	PMID
ionotropic glutamate receptor signaling pathway	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-glutamate

cellular response to nitrogen compound [inference]

cellular response to L-glutamate

cellular response to oxygen-containing compound [inference]

cellular response to L-glutamate

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

startle response

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

animal organ development [inference]

brain development

response to stimulus [inference]

response to external stimulus [inference]

startle response

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-glutamate

response to L-glutamate [inference]

cellular response to L-glutamate

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-glutamate

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-glutamate

cellular response to nitrogen compound [inference]

cellular response to L-glutamate

cellular response to oxygen-containing compound [inference]

cellular response to L-glutamate

response to nitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to L-glutamate

response to L-glutamate [inference]

cellular response to L-glutamate

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to L-glutamate

response to L-glutamate [inference]

cellular response to L-glutamate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to L-glutamate

cellular response to nitrogen compound [inference]

cellular response to L-glutamate

cellular response to oxygen-containing compound [inference]

cellular response to L-glutamate

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

regulation of sensory perception [inference]

regulation of sensory perception of pain

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of synaptic plasticity

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	TAS	Reactome
plasma membrane	EXP	PMID PMID
plasma membrane	NAS	PMID
plasma membrane	TAS	Reactome Reactome Reactome
plasma membrane	IDA	PMID PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
glutamate-gated receptor activity	IDA	PMID
glutamate-gated receptor activity	IEA	GO_REF
NMDA glutamate receptor activity	ISS	GO_REF
NMDA glutamate receptor activity	TAS	PMID
NMDA glutamate receptor activity	IDA	PMID PMID PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

voltage-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

voltage-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

voltage-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

binding [inference]

amino acid binding [inference]

glutamate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

glutamate binding

organic acid binding [inference]

carboxylic acid binding [inference]

glutamate binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
92	N-linked (GlcNAc...) asparagine	24190977		UniProt GlyGen
352	N-linked (GlcNAc...) asparagine			UniProt GlyGen
366	N-linked (GlcNAc...) asparagine			UniProt GlyGen
384	N-linked (GlcNAc...) asparagine			UniProt GlyGen
467	N-linked (GlcNAc...) asparagine		G70441OD	UniProt GlyGen
569	N-linked (GlcNAc...) asparagine			UniProt GlyGen
715			G80920RR	GlyGen
1309				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Assembly and cell surface presentation of NMDA receptors	Homo sapiens
Long-term potentiation	Homo sapiens
Negative regulation of NMDA receptor-mediated neuronal transmission	Homo sapiens
Neurexins and neuroligins	Homo sapiens
RAF/MAP kinase cascade	Homo sapiens
Ras activation upon Ca2+ influx through NMDA receptor	Homo sapiens
Synaptic adhesion-like molecules	Homo sapiens
Unblocking of NMDA receptors, glutamate binding and activation	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080456	developmental and epileptic encephalopathy 46	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements