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Slit homolog 3 protein

Summary

UniProt ID: O75094
Gene Symbol: SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336
Gene ID: 6586
Organism: Homo sapiens (human)

External Links

GlyConnect

Slit homolog 3 protein

GlyGen

O75094

PubChem

O75094

The O-GlcNAc Database

O75094

RaftProt

O75094

O-GlcNAcAtlas

O75094

Re-Glyco

O75094

Annotation

Keyword: Alternative splicing Developmental protein Differentiation Disulfide bond EGF-like domain Glycoprotein Leucine-rich repeat Neurogenesis Proteomics identification Reference proteome Repeat Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
aortic valve morphogenesis	ISS	GO_REF
aortic valve morphogenesis	IEA	GO_REF
atrioventricular valve morphogenesis	ISS	GO_REF
atrioventricular valve morphogenesis	IEA	GO_REF
axon guidance	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Roundabout signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development [inference]

apoptotic process involved in luteolysis

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

cardiac septum morphogenesis [inference]

ventricular septum morphogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisol

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisol

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisol

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to cortisol

response to ketone [inference]

response to cortisol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of cell growth

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Roundabout signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

Displaying **all 2** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
mitochondrion	NAS	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
calcium ion binding	NAS	PMID
calcium ion binding	IEA	GO_REF
heparin binding	IBA	GO_REF
Roundabout binding	IBA	GO_REF
Roundabout binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

Roundabout binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 17 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
72	N-linked (GlcNAc...) asparagine	37074911	G41071NU G80920RR G42124LM G77547TA G62765YT	UniProt GlyGen
192	N-linked (GlcNAc...) asparagine	37074911	G80920RR G62765YT G28541PG G31852PQ G39446WN G41247ZX G02815KT	UniProt GlyGen
563	N-linked (GlcNAc...) asparagine			UniProt GlyGen
622	N-linked (GlcNAc...) asparagine	37074911	G92135MA G80920RR	UniProt GlyGen
784	N-linked (GlcNAc...) asparagine			UniProt GlyGen
792	N-linked (GlcNAc...) asparagine			UniProt GlyGen
797	N-linked (GlcNAc...) asparagine			UniProt GlyGen
928	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
1008	N-linked (GlcNAc...) asparagine			UniProt GlyGen
1025	N-linked (GlcNAc...) asparagine			UniProt GlyGen