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Netrin-1 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-373752

PubChem

R-HSA-373752

Description

Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 17 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75093	Slit homolog 1 protein	KIAA0813 MEGF4 SLIL1 SLIT1	view
O75094	Slit homolog 3 protein	KIAA0814 MEGF5 SLIL2 SLIT3 UNQ691/PRO1336	view
O94813	Slit homolog 2 protein	SLIL3 SLIT2	view
O95631	Netrin-1	NTN1 NTN1L	view
P15311	Ezrin	EZR VIL2	view
P43146	Netrin receptor DCC	DCC IGDCC1	view
Q04759	Protein kinase C theta type	PRKCQ PRKCT	view
Q6NW40	Repulsive guidance molecule B	RGMB	view
Q6ZN44	Netrin receptor UNC5A	KIAA1976 UNC5A UNC5H1	view
Q6ZVN8	Hemojuvelin	HFE2 HJV RGMC	view

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