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Dickkopf-related protein 1

Summary

UniProt ID

O94907

Gene Symbol

DKK1
UNQ492/PRO1008

Gene ID

22943

Organism

Homo sapiens (human)

External Links

GlycoProtDB: GPDB0011257
GlyGen: O94907
PubChem: O94907
Re-Glyco: O94907

Annotation

Keyword

3D-structure
Developmental protein
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Wnt signaling pathway

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
plasma membrane
early endosome membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 41 in total

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GO Term
regulation of synaptic transmission, glutamatergic
endoderm formation
mesoderm formation
learning or memory
positive regulation of gene expression
negative regulation of ossification
negative regulation of apoptotic process
negative regulation of mesodermal cell fate specification
regulation of endodermal cell fate specification
positive regulation of Wnt signaling pathway, calcium modulating pathway

Displaying **all 4** entries
GO Term
growth factor activity
low-density lipoprotein particle receptor binding
co-receptor binding
receptor antagonist activity

Annotation information from UniProt.

Sequence

MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 21 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
44			G57321FI	GlyGen
61	O-linked (GalNAc...) serine	21805521	G57321FI	UniProt GlyGen
68				GlyGen
74			G57321FI	GlyGen
76			G57321FI	GlyGen
99			G57321FI	GlyGen
131				GlycoProtDB GlyGen
148			G57321FI	GlyGen
153			G57321FI	GlyGen
155			G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Homo sapiens
Signaling by LRP5 mutants	Homo sapiens
TCF dependent signaling in response to WNT	Homo sapiens