Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

Summary
UniProt ID
O95803
Gene Symbol
  • NDST3
  • HSST3
Organism
Homo sapiens (human)
External Links
The Human Metabolome Database
HMDBP11855
Annotation
Keyword
  • Alternative splicing
  • Disulfide bond
  • Glycoprotein
  • Golgi apparatus
  • Hydrolase
  • Multifunctional enzyme
  • Reference proteome
  • Signal-anchor
  • Transferase
  • Transmembrane helix
Gene Ontology (GO)
Sequence
MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPYQLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVLIDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKTPENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKKFALEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLSSYYRDHNVELSKLLHKLGQPLPSWLRQELQKVR
Glycosylation Sites
Displaying all 6 entries
Position Description PubMed ID GlyTouCan ID Source
146 N-linked (GlcNAc...) asparagine
226 N-linked (GlcNAc...) asparagine
342 N-linked (GlcNAc...) asparagine
392 N-linked (GlcNAc...) asparagine
658 N-linked (GlcNAc...) asparagine
794 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
HS-GAG biosynthesis Homo sapiens
Disease
Displaying entries 1 - 10 of 12 in total
DO ID Disease Name Source
DOID:0060215 Balo concentric sclerosis
DOID:10588 adrenoleukodystrophy
DOID:14320 generalized anxiety disorder
DOID:1470 major depressive disorder
DOID:1595 melancholic depression
DOID:1596 depressive disorder
DOID:2030 anxiety disorder
DOID:2848 obsolete melancholia
DOID:331 central nervous system disease
DOID:4964 neurotic disorder

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024