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HS-GAG biosynthesis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2022928

PubChem

R-HSA-2022928

Description

Heparan sulfate (HS) and heparin (sometimes collectively called HS-GAG) chains consist of the variably sulfated repeating disaccharide units heparan (Ido-GlcNAc) or heparosan (GlcA-GlcNAc). Heparin is exclusively made in mast cells whereas HS is made by virtually every type of cell in the body. As the chain length increases, the polysaccharides can undergo modifications such as epimerisation of glucuronic acid to iduronic acid and deacetylation and sulfation of GlcNAc to form sulfated glucosamine (Stringer & Gallagher 1997, Sasisekharan & Venkataraman 2000).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 32 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00468	Agrin	AGRIN AGRN	view
O14792	Heparan sulfate glucosamine 3-O-sulfotransferase 1	3OST 3OST1 HS3ST1	view
O43909	Exostosin-like 3	EXTL1L EXTL3 EXTR1 KIAA0519	view
O60243	Heparan-sulfate 6-O-sulfotransferase 1	HS6ST HS6ST1	view
O75056	Syndecan-3	KIAA0468 SDC3	view
O75487	Glypican-4	GPC4 UNQ474/PRO937	view
O94923	D-glucuronyl C5-epimerase	GLCE KIAA0836	view
O95803	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3	HSST3 NDST3 UNQ2544/PRO4998	view
P18827	Syndecan-1	SDC SDC1	view
P31431	Syndecan-4	SDC4	view

Displaying **all 2** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005327	O00468	Agrin	view
GL_005334	P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	view

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