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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Epidermal growth factor receptor
Summary
- UniProt ID
- P00533
- Gene Symbol
-
- EGFR
- ERBB
- ERBB1
- HER1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011271
- GlyConnect
- GlyGen
- P00533
- PubChem
- P00533
- The Human Metabolome Database
- HMDBP01456
- The O-GlcNAc Database
- P00533
- RaftProt
- P00533
- O-GlcNAcAtlas
- P00533
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Developmental protein
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Host cell receptor for virus entry
- Host-virus interaction
- Hydroxylation
- Isopeptide bond
- Methylation
- Nucleus
- Palmitate
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cellular response to cadmium ion |
| cellular response to epidermal growth factor stimulus |
| cellular response to estradiol stimulus |
| GO Term |
|---|
| Golgi membrane |
| endosome |
| endoplasmic reticulum membrane |
| basal plasma membrane |
| cell surface |
| basolateral plasma membrane |
| apical plasma membrane |
| perinuclear region of cytoplasm |
| extracellular space |
| nucleus |
| GO Term |
|---|
| kinase binding |
| protein kinase binding |
| protein phosphatase binding |
| ubiquitin protein ligase binding |
| identical protein binding |
| cadherin binding |
| epidermal growth factor binding |
| actin filament binding |
| ATPase binding |
| MAP kinase kinase kinase activity |
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 56 | N-linked (GlcNAc...) (complex) asparagine; atypical; partial | |||
| 73 | N-linked (GlcNAc...) asparagine; atypical |
|
||
| 128 | N-linked (GlcNAc...) asparagine | |||
| 175 | N-linked (GlcNAc...) asparagine | |||
| 196 | N-linked (GlcNAc...) asparagine | |||
| 271 |
|
|||
| 352 | N-linked (GlcNAc...) asparagine | |||
| 361 | N-linked (GlcNAc...) asparagine | |||
| 364 |
|
|||
| 380 |
|
G48414YA
G83461WR
G84452RH
G23863VK
G78059CC
G27058EU
G10488MI
G41071NU
G06356OH
G80920RR
G90659AW
G14972EH
G87661QW
G25079LO
G42124LM
G46687AB
G49874UX
G41247ZX
G02815KT
G12793SR
G93656SY
G47518TP
G52527GH
G59536GA
G66760KM
G83460ZZ
G86182NS
G70101JE
G02886BB
G59924QI
G62765YT
G64527OM
G05724UK
G31852PQ
G39188ZX
G06110VR
G92050GC
G82830MN
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Homo sapiens |
| Clathrin-mediated endocytosis | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Constitutive Signaling by EGFRvIII | Homo sapiens |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Homo sapiens |
| Downregulation of ERBB2 signaling | Homo sapiens |
| EGFR Transactivation by Gastrin | Homo sapiens |
| EGFR downregulation | Homo sapiens |
| EGFR interacts with phospholipase C-gamma | Homo sapiens |
| ERBB2 Activates PTK6 Signaling | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
