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MIRAGE
Prothrombin

Summary
UniProt ID
P00734
Gene Symbol
  • F2
Gene ID
2147
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011275
GlyConnect
GlyGen
P00734
PubChem
P00734
The Human Metabolome Database
HMDBP13521
RaftProt
P00734
Re-Glyco
P00734
Annotation
Keyword
  • 3D-structure
  • Acute phase
  • Calcium
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Kringle
  • Pharmaceutical
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Thrombophilia
  • Zymogen
Gene Ontology (GO)
Displaying all 8 entries
GO Term
extracellular region
extracellular space
plasma membrane
collagen-containing extracellular matrix
endoplasmic reticulum lumen
Golgi lumen
extracellular exosome
blood microparticle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 13 in total
Position Description PubMed ID GlyTouCan ID Source
78
121 N-linked (GlcNAc...) (complex) asparagine
143 N-linked (GlcNAc...) (complex) asparagine
145
192
199
205
207
260
315
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 11 - 14 of 14 in total
Pathway Name Organism
Regulation of IGF Activity by IGFBP Homo sapiens
Removal of aminoterminal propeptides from gamma-carboxylated proteins Homo sapiens
Thrombin signalling through proteinase activated receptors (PARs) Homo sapiens
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Homo sapiens
Disease
Displaying entries 1 - 10 of 22 in total
DO ID Disease Name Source
DOID:0060903 thrombosis
DOID:0111907 thrombophilia due to thrombin defect
DOID:10003 sensorineural hearing loss
DOID:10159 osteonecrosis
DOID:10591 pre-eclampsia
DOID:10608 celiac disease
DOID:12134 factor VIII deficiency
DOID:12205 dengue disease
DOID:12259 hemophilia B
DOID:13001 carotid stenosis
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025