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Standards Ontologies Notations
Coagulation factor IX

Summary
UniProt ID
P00740
Gene Symbol
  • F9
Organism
Homo sapiens (human)
External Links
GlyConnect
GlyGen
P00740
PubChem
P00740
The Human Metabolome Database
HMDBP01730
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Hemophilia
  • Hydroxylation
  • Magnesium
  • Metal-binding
  • Pharmaceutical
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Sulfation
  • Thrombophilia
  • Zymogen
Gene Ontology (GO)
Displaying all 3 entries
GO Term
zymogen activation
proteolysis
blood coagulation
Annotation information from UniProt.
Sequence
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 11 in total
Position Description PubMed ID GlyTouCan ID Source
85 O-linked (GalNAc...) threonine
90
99 O-linked (Glc...) serine
107 O-linked (Fuc...) serine
203 N-linked (GlcNAc...) asparagine
205 O-linked (GalNAc...) threonine; alternate
213 N-linked (GlcNAc...) asparagine
215 O-linked (GalNAc...) threonine
218
225 O-linked (GalNAc...) threonine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 12 in total
Pathway Name Organism
Defective F9 activation Homo sapiens
Defective F9 secretion Homo sapiens
Defective F9 variant does not activate FX Homo sapiens
Defective cofactor function of FVIIIa variant Homo sapiens
Defective factor IX causes thrombophilia Homo sapiens
Defective gamma-carboxylation of F9 Homo sapiens
Extrinsic Pathway of Fibrin Clot Formation Homo sapiens
Gamma-carboxylation of protein precursors Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Protein hydroxylation Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024