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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Coagulation factor IX
Summary
- UniProt ID
- P00740
- Gene Symbol
-
- F9
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P00740
- PubChem
- P00740
- The Human Metabolome Database
- HMDBP01730
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hemophilia
- Hydroxylation
- Magnesium
- Metal-binding
- Pharmaceutical
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sulfation
- Thrombophilia
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| proteolysis |
| blood coagulation |
| zymogen activation |
| GO Term |
|---|
| endoplasmic reticulum lumen |
| Golgi lumen |
| extracellular region |
| extracellular space |
| plasma membrane |
| collagen-containing extracellular matrix |
| extracellular exosome |
| GO Term |
|---|
| serine-type endopeptidase activity |
| calcium ion binding |
| metal ion binding |
| endopeptidase activity |
Sequence
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 85 | O-linked (GalNAc...) threonine | |||
| 90 |
|
|||
| 99 | O-linked (Glc...) serine |
|
||
| 107 | O-linked (Fuc...) serine | |||
| 203 | N-linked (GlcNAc...) asparagine |
|
||
| 205 | O-linked (GalNAc...) threonine; alternate | |||
| 213 | N-linked (GlcNAc...) asparagine |
|
||
| 215 | O-linked (GalNAc...) threonine | |||
| 218 |
|
|||
| 225 | O-linked (GalNAc...) threonine |
G70649KP
G10651WD
G45637XA
G81006GJ
G57321FI
G50236GJ
G70593HA
G27608TI
G76163CP
G43417UB
G29068FM
G18717LR
G74722FL
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | Homo sapiens |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | Homo sapiens |
