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Pro-epidermal growth factor

Summary

UniProt ID

P01132

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003252
PubChem: P01132
The O-GlcNAc Database: P01132

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 39 in total

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GO Term
cerebellar granule cell precursor proliferation
positive regulation of cerebellar granule cell precursor proliferation
canonical Wnt signaling pathway
positive regulation of DNA-templated transcription
positive regulation of receptor internalization
epidermal growth factor receptor signaling pathway
positive regulation of peptidyl-threonine phosphorylation
angiogenesis
positive regulation of endothelial cell proliferation
cell population proliferation

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
plasma membrane
extracellular exosome

Displaying **all 8** entries
GO Term
Wnt-protein binding
Wnt receptor activity
receptor ligand activity
guanyl-nucleotide exchange factor activity
epidermal growth factor receptor binding
growth factor activity
calcium ion binding
transmembrane receptor protein tyrosine kinase activator activity

Annotation information from UniProt.

Sequence

MPWGRRPTWLLLAFLLVFLKISILSVTAWQTGNCQPGPLERSERSGTCAGPAPFLVFSQGKSISRIDPDGTNHQQLVVDAGISADMDIHYKKERLYWVDVERQVLLRVFLNGTGLEKVCNVERKVSGLAIDWIDDEVLWVDQQNGVITVTDMTGKNSRVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDVKTLLETGGISVLTLDVLDKRLFWVQDSGEGSHAYIHSCDYEGGSVRLIRHQARHSLSSMAFFGDRIFYSVLKSKAIWIANKHTGKDTVRINLHPSFVTPGKLMVVHPRAQPRTEDAAKDPDPELLKQRGRPCRFGLCERDPKSHSSACAEGYTLSRDRKYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQCHELVSCPGNVSKCSHGCVLTSDGPRCICPAGSVLGRDGKTCTGCSSPDNGGCSQICLPLRPGSWECDCFPGYDLQSDRKSCAASGPQPLLLFANSQDIRHMHFDGTDYKVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQRERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHHRIIIQERISRPRGIAVHPRARRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKRRRLIQNDVGHPFSLAVFEDHLWVSDWAIPSVIRVNKRTGQNRVRLQGSMLKPSSLVVVHPLAKPGADPCLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMCLPQDYPILSGENADLSKEVTSLSNSTQAEVPDDDGTESSTLVAEIMVSGMNYEDDCGPGGCGSHARCVSDGETAECQCLKGFARDGNLCSDIDECVLARSDCPSTSSRCINTEGGYVCRCSEGYEGDGISCFDIDECQRGAHNCGENAACTNTEGGYNCTCAGRPSSPGLSCPDSTAPSLLGEDGHHLDRNSYPGCPSSYDGYCLNGGVCMHIESLDSYTCNCVIGYSGDRCQTRDLRWWELRHAGYGQKHDIMVVAVCMVALVLLLVLGMWGTYYYRTRKQLSNPPKNPCDEPSGSVSSSGPNSSSGAAVASCPQPWFVVLEKHQDPKNGSLPADGTNGAVVDAGLSPSLQLGSVHLTSWRQKPHIDGMGTGQSCWIPPSSDRGPQEIEGNSHLPSYRPVGPEKLHSLQSANGSCHERAPDLPRQTEPVQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	GlyTouCan ID	Source
111	N-linked (GlcNAc...) asparagine		GlycoProtDB UniProt
410	N-linked (GlcNAc...) asparagine		GlycoProtDB UniProt
810	N-linked (GlcNAc...) asparagine		UniProt
944	N-linked (GlcNAc...) asparagine		UniProt
		G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 21 in total

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Pathway Name	Organism
Cargo recognition for clathrin-mediated endocytosis	Mus musculus
Clathrin-mediated endocytosis	Mus musculus
Downregulation of ERBB2 signaling	Mus musculus
EGFR downregulation	Mus musculus
EGFR interacts with phospholipase C-gamma	Mus musculus
ERBB2 Activates PTK6 Signaling	Mus musculus
ERBB2 Regulates Cell Motility	Mus musculus
Extra-nuclear estrogen signaling	Mus musculus
GAB1 signalosome	Mus musculus
GRB2 events in EGFR signaling	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements