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MIRAGE
EGFR downregulation

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CBLEGF-like ligands:p-6Y-EGFR:CBLEGF-like ligands:p-6Y EGFR dimerEGF-like ligands:p-6Y-EGFR:p-Y371-CBLATPADPSPRY1/2EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2UbEGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBLCBL:GRB2Grb2EGF-like ligands:p-6Y-EGFR:CBL:GRB2EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2CBL:SPRY1/2Q9QXV8Beta-Pix:CDC42:GTPCBL:Beta-Pix:CDC42:GTPEGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:EndophilinEGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85CIN85:endophilinEGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTPUb-Beta-Pix:CDC42:GTPEPN1EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15Q60902EPS15:HGS:STAMEGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15SPRY1/2H2OPiEGF:p-6Y-EGFR dimerEGF:p-EGFR dimer dephosphorylated at Y1172 (Y1148)EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAMPIP2EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025