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Protransforming growth factor alpha

Summary

UniProt ID

P01134

Gene Symbol

Tgfa

Gene ID

24827

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P01134
Re-Glyco: P01134

Annotation

Keyword

Cell membrane
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Mitogen
Palmitate
Reference proteome
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
cytoplasmic vesicle
cell surface
basolateral plasma membrane
perinuclear region of cytoplasm
extracellular space

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 14 in total

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GO Term
cell surface receptor signaling pathway
positive regulation of cell population proliferation
negative regulation of apoptotic process
positive regulation of mitotic nuclear division
positive regulation of epithelial cell proliferation
ERBB2-EGFR signaling pathway
response to xenobiotic stimulus
positive regulation of MAPK cascade
mammary gland alveolus development
hepatocyte proliferation

Displaying **all 4** entries
GO Term
growth factor activity
epidermal growth factor receptor binding
receptor ligand activity
transmembrane receptor protein tyrosine kinase activator activity

Annotation information from UniProt.

Sequence

MVPAAGQLALLALGILVAVCQALENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
25	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 14 in total

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Pathway Name	Organism
COPII-mediated vesicle transport	Rattus norvegicus
Cargo concentration in the ER	Rattus norvegicus
Cargo recognition for clathrin-mediated endocytosis	Rattus norvegicus
Clathrin-mediated endocytosis	Rattus norvegicus
EGFR downregulation	Rattus norvegicus
EGFR interacts with phospholipase C-gamma	Rattus norvegicus
Extra-nuclear estrogen signaling	Rattus norvegicus
GAB1 signalosome	Rattus norvegicus
GRB2 events in EGFR signaling	Rattus norvegicus
PI3K/AKT Signaling	Rattus norvegicus