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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Apolipoprotein E
Summary
- UniProt ID
- P02649
- Gene Symbol
-
- APOE
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alzheimer disease
- Amyloidosis
- Cholesterol metabolism
- Chylomicron
- Direct protein sequencing
- Disease variant
- Endosome
- Extracellular matrix
- Glycation
- HDL
- Heparin-binding
- Host-virus interaction
- Hyperlipidemia
- Lipid transport
- Lipid-binding
- Neurodegeneration
- Oxidation
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- VLDL
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| nucleus |
| cytoplasm |
| Golgi apparatus |
| plasma membrane |
| membrane |
| extracellular matrix |
| melanosome |
| collagen-containing extracellular matrix |
Sequence
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 26 | O-linked (GalNAc...) threonine | |||
| 34 |
|
|||
| 36 | O-linked (GalNAc...) threonine | |||
| 93 | N-linked (Glc) (glycation) lysine |
|
||
| 210 |
|
|||
| 212 | O-linked (GalNAc...) threonine | |||
| 215 |
|
|||
| 301 |
|
|||
| 307 | O-linked (GalNAc...) threonine | |||
| 308 | O-linked (GalNAc...) serine |
G29931IJ
G43417UB
G57321FI
G53434XO
G63628AV
G29068FM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Amyloid fiber formation | Homo sapiens |
| Chylomicron assembly | Homo sapiens |
| Chylomicron clearance | Homo sapiens |
| Chylomicron remodeling | Homo sapiens |
| HDL remodeling | Homo sapiens |
| LXRs regulate gene expression linked to cholesterol transport and efflux | Homo sapiens |
| Nuclear signaling by ERBB4 | Homo sapiens |
| Post-translational protein phosphorylation | Homo sapiens |
| Regulation of IGF Activity by IGFBP | Homo sapiens |
| Retinoid metabolism and transport | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
