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MIRAGE
Fibrinogen alpha chain

Summary
UniProt ID
P02671
Gene Symbol
  • FGA
Gene ID
2243
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011303
GlyConnect
GlyGen
P02671
PubChem
P02671
The Human Metabolome Database
HMDBP13512
RaftProt
P02671
Re-Glyco
P02671
Annotation
Keyword
  • 3D-structure
  • Adaptive immunity
  • Alternative splicing
  • Amyloid
  • Amyloidosis
  • Blood coagulation
  • Calcium
  • Coiled coil
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Hydroxylation
  • Innate immunity
  • Isopeptide bond
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying entries 1 - 10 of 14 in total
GO Term
platelet alpha granule lumen
extracellular vesicle
extracellular region
fibrinogen complex
extracellular space
plasma membrane
collagen-containing extracellular matrix
endoplasmic reticulum
endoplasmic reticulum lumen
external side of plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 38 in total
Position Description PubMed ID GlyTouCan ID Source
98
101
107
250
252
272
283
297
315
318
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 21 in total
Pathway Name Organism
Amyloid fiber formation Homo sapiens
Common Pathway of Fibrin Clot Formation Homo sapiens
ER-Phagosome pathway Homo sapiens
GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens
IRAK4 deficiency (TLR2/4) Homo sapiens
Integrin cell surface interactions Homo sapiens
Integrin signaling Homo sapiens
MAP2K and MAPK activation Homo sapiens
MyD88 deficiency (TLR2/4) Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Homo sapiens
Disease
Displaying all 4 entries
DO ID Disease Name Source
DOID:0050636 familial visceral amyloidosis
DOID:0112313 brain small vessel disease
DOID:2236 congenital afibrinogenemia
DOID:2452 thrombophilia
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025