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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
High affinity nerve growth factor receptor
Summary
- UniProt ID
- P04629
- Gene Symbol
-
- NTRK1
- MTC
- TRK
- TRKA
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P04629
- PubChem
- P04629
- The Human Metabolome Database
- HMDBP01503
- The O-GlcNAc Database
- P04629
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Chromosomal rearrangement
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- Endosome
- Glycoprotein
- Immunoglobulin domain
- Leucine-rich repeat
- Neurogenesis
- Phosphoprotein
- Proto-oncogene
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| endosome membrane |
| early endosome |
| late endosome |
| cell surface |
| plasma membrane |
| axon |
| protein-containing complex |
| dendrite |
| neuronal cell body |
| receptor complex |
Sequence
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 67 | N-linked (GlcNAc...) asparagine |
|
||
| 95 | N-linked (GlcNAc...) asparagine |
|
||
| 121 | N-linked (GlcNAc...) asparagine |
|
||
| 188 | N-linked (GlcNAc...) asparagine |
|
||
| 202 | N-linked (GlcNAc...) asparagine |
|
||
| 253 | N-linked (GlcNAc...) asparagine |
|
||
| 262 | N-linked (GlcNAc...) asparagine |
|
||
| 281 | N-linked (GlcNAc...) asparagine |
|
||
| 318 | N-linked (GlcNAc...) asparagine |
|
||
| 323 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| ARMS-mediated activation | Homo sapiens |
| NGF-independant TRKA activation | Homo sapiens |
| PI3K/AKT activation | Homo sapiens |
| PLC-gamma1 signalling | Homo sapiens |
| Retrograde neurotrophin signalling | Homo sapiens |
| Signalling to RAS | Homo sapiens |
| Signalling to STAT3 | Homo sapiens |
| Signalling to p38 via RIT and RIN | Homo sapiens |
| TRKA activation by NGF | Homo sapiens |
