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High affinity nerve growth factor receptor

Summary

UniProt ID

P04629

Gene Symbol

NTRK1
MTC
TRK
TRKA

Organism

Homo sapiens (human)

External Links

GlyGen: P04629
PubChem: P04629
The Human Metabolome Database: HMDBP01503
The O-GlcNAc Database: P04629

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Chromosomal rearrangement
Developmental protein
Differentiation
Disease variant
Disulfide bond
Endosome
Glycoprotein
Immunoglobulin domain
Leucine-rich repeat
Neurogenesis
Phosphoprotein
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of protein phosphorylation
protein phosphorylation
learning or memory
negative regulation of cell population proliferation
peptidyl-tyrosine phosphorylation
B cell differentiation
positive regulation of angiogenesis
neuron development
programmed cell death involved in cell development
positive regulation of neuron projection development

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GO Term
plasma membrane
axon
protein-containing complex
dendrite
neuronal cell body
receptor complex
recycling endosome membrane
early endosome membrane
late endosome membrane
endosome membrane

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GO Term
GPI-linked ephrin receptor activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
ATP binding
nerve growth factor receptor activity
neurotrophin binding
nerve growth factor binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase binding

Annotation information from UniProt.

Sequence

MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 14 in total

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Position	Description	PubMed ID	Source
67	N-linked (GlcNAc...) asparagine		UniProt GlyGen
95	N-linked (GlcNAc...) asparagine	17196528	UniProt GlyGen
121	N-linked (GlcNAc...) asparagine	17196528	UniProt GlyGen
188	N-linked (GlcNAc...) asparagine	17196528	UniProt GlyGen
202	N-linked (GlcNAc...) asparagine		UniProt GlyGen
253	N-linked (GlcNAc...) asparagine		UniProt GlyGen
262	N-linked (GlcNAc...) asparagine	17196528	UniProt GlyGen
281	N-linked (GlcNAc...) asparagine	17196528	UniProt GlyGen
318	N-linked (GlcNAc...) asparagine		UniProt GlyGen
323	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
ARMS-mediated activation	Homo sapiens
NGF-independant TRKA activation	Homo sapiens
PI3K/AKT activation	Homo sapiens
PLC-gamma1 signalling	Homo sapiens
Retrograde neurotrophin signalling	Homo sapiens
Signalling to RAS	Homo sapiens
Signalling to STAT3	Homo sapiens
Signalling to p38 via RIT and RIN	Homo sapiens
TRKA activation by NGF	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements