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TRKA activation by NGF

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-187042

PubChem

R-HSA-187042

Description

Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01138	Beta-nerve growth factor	NGF NGFB	view
P04629	High affinity nerve growth factor receptor	MTC NTRK1 TRK TRKA	view

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