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Glycan Structure Repository
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Glycomics MS raw data Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Repository for lectin-assisted multimodality data
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MIRAGE
Integrin beta-3
Summary
- UniProt ID
- P05106
- Gene Symbol
-
- GP3A
- ITGB3
- Gene ID
- 3690
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell adhesion
- Cell junction
- Cell membrane
- Cell projection
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Host cell receptor for virus entry
- Host-virus interaction
- Integrin
- Magnesium
- Metal-binding
- Phosphoprotein
- Postsynaptic cell membrane
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| integrin alphaIIb-beta3 complex |
| alphav-beta3 integrin-vitronectin complex |
| alpha9-beta1 integrin-ADAM8 complex |
| glycinergic synapse |
| lamellipodium membrane |
| nucleus |
| plasma membrane |
| cell-cell junction |
| protein-containing complex |
| GO Term |
|---|
| cell adhesion molecule binding |
| extracellular matrix binding |
| fibronectin binding |
| platelet-derived growth factor receptor binding |
| fibrinogen binding |
Sequence
MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 125 | N-linked (GlcNAc...) asparagine | |||
| 346 | N-linked (GlcNAc...) asparagine |
|
||
| 397 | N-linked (GlcNAc...) asparagine | |||
| 478 | N-linked (GlcNAc...) asparagine | |||
| 585 | N-linked (GlcNAc...) asparagine |
|
||
| 680 | N-linked (GlcNAc...) asparagine |
G27947YN
G94470IW
G26330YA
G00912UN
G48414YA
G27058EU
G06356OH
G59626AS
G80920RR
G45504EY
G62765YT
G28541PG
G95865ZB
G31852PQ
G41247ZX
G02815KT
G08290VR
G46503DX
G83633GK
G87661QW
G83460ZZ
G70101JE
G77547TA
G64527OM
G05724UK
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| ECM proteoglycans | Homo sapiens |
| Elastic fibre formation | Homo sapiens |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | Homo sapiens |
| Integrin cell surface interactions | Homo sapiens |
| Integrin signaling | Homo sapiens |
| MAP2K and MAPK activation | Homo sapiens |
| Molecules associated with elastic fibres | Homo sapiens |
| PECAM1 interactions | Homo sapiens |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | Homo sapiens |
| Platelet degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050864 | non-arteritic anterior ischemic optic neuropathy | |
| DOID:0060691 | platelet-type bleeding disorder 16 | |
| DOID:1588 | thrombocytopenia | |
| DOID:2218 | blood platelet disease | |
| DOID:2219 | Glanzmann's thrombasthenia | |
| DOID:2841 | asthma | |
| DOID:5844 | myocardial infarction | |
| DOID:783 | end stage renal disease | |
| DOID:8924 | autoimmune thrombocytopenic purpura | |
| DOID:9119 | acute myeloid leukemia |
