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Insulin receptor

Summary

UniProt ID

P06213

Gene Symbol

INSR

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011401

GlyConnect

1402

GlyGen

P06213

PubChem

P06213

The Human Metabolome Database

HMDBP01521

The O-GlcNAc Database

P06213

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Carbohydrate metabolism
Cell membrane
Cleavage on pair of basic residues
Diabetes mellitus
Direct protein sequencing
Disease variant
Disulfide bond
Endosome
Glycoprotein
Lysosome
Phosphoprotein
Receptor
Reference proteome
Repeat
S-nitrosylation
Signal
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

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GO Term
positive regulation of protein phosphorylation
heart morphogenesis
protein phosphorylation
G protein-coupled receptor signaling pathway
memory
positive regulation of cell population proliferation
insulin receptor signaling pathway
epidermis development
male gonad development
peptidyl-tyrosine phosphorylation

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GO Term
extracellular exosome
caveola
endosome membrane
late endosome
external side of plasma membrane
neuronal cell body membrane
lysosome
plasma membrane
insulin receptor complex
membrane

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GO Term
PTB domain binding
protein domain specific binding
insulin-like growth factor I binding
insulin-like growth factor II binding
identical protein binding
insulin receptor substrate binding
amyloid-beta binding
insulin-like growth factor receptor binding
ATP binding
GTP binding

Annotation information from UniProt.

Sequence

MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
43	N-linked (GlcNAc...) asparagine	16894147 23302862 2983222		UniProt GlyGen
52	N-linked (GlcNAc...) asparagine	16894147 23302862		UniProt GlyGen
105	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
138	N-linked (GlcNAc...) asparagine	16894147 23302862	G11101UV G72951AH G83460ZZ G80920RR G62765YT G31852PQ	UniProt GlyGen
242	N-linked (GlcNAc...) asparagine	16894147 19159218 23302862	G15664MX G72747WU G92406TI G80920RR G90659AW G62765YT G64527OM G10486CT G05049YU G31852PQ G41247ZX G02815KT	UniProt GlyGen GlyConnect
282	N-linked (GlcNAc...) asparagine	16894147 23302862	G45395BF G07246CJ G14972EH G08918WF G00912UN G87661QW G83646BJ G27058EU G83460ZZ G41071NU G59626AS G80920RR G90659AW G62765YT G47644PP G02815KT	UniProt GlyGen
322	N-linked (GlcNAc...) asparagine			UniProt GlyGen
364	N-linked (GlcNAc...) asparagine	16894147	G31852PQ	UniProt GlyGen
424	N-linked (GlcNAc...) asparagine	16894147	G05962QB G12341GU G70232NH G77582RK G20312EM G80075MS G57776ZS G60834IK G45395BF G83646BJ G04657PL G27058EU G41071NU G80920RR	UniProt GlyGen GlyConnect
445	N-linked (GlcNAc...) asparagine	16894147 19349973	G39471UU G05962QB G55132BD G37818NZ G35541EV G93718GY G13131HA G49755GI G20312EM G80075MS G57776ZS G16125XL G29545VG G68490OW G60834IK G86880BF G27947YN G80479JV G85282JO G87123QX G96577RX G79666IR G81263BG G45395BF G07246CJ G20706XG G10819WX G40926MX G14972EH G43223CG G08918WF G49906RN G58087IP G70441OD G87661QW G83646BJ G15664MX G04657PL G27058EU G83460ZZ G41071NU G80920RR G90659AW G62765YT	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
IRS activation	Homo sapiens
Insulin receptor recycling	Homo sapiens
Insulin receptor signalling cascade	Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Homo sapiens
Signal attenuation	Homo sapiens
Signaling by Insulin receptor	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements