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MIRAGE
Coagulation factor VII

Summary
UniProt ID
P08709
Gene Symbol
  • F7
Gene ID
2155
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P08709
PubChem
P08709
The Human Metabolome Database
HMDBP02013
RaftProt
P08709
Re-Glyco
P08709
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Blood coagulation
  • Calcium
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Hydroxylation
  • Pharmaceutical
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Zymogen
Gene Ontology (GO)
Displaying all 8 entries
GO Term
extracellular region
extracellular space
plasma membrane
vesicle
collagen-containing extracellular matrix
endoplasmic reticulum lumen
Golgi lumen
serine-type peptidase complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
112 O-linked (Glc...) serine; alternate
120 O-linked (Fuc) serine
205 N-linked (GlcNAc...) asparagine
382 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 5 entries
Pathway Name Organism
BMAL1:CLOCK,NPAS2 activates circadian gene expression Homo sapiens
Extrinsic Pathway of Fibrin Clot Formation Homo sapiens
Gamma-carboxylation of protein precursors Homo sapiens
Removal of aminoterminal propeptides from gamma-carboxylated proteins Homo sapiens
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Homo sapiens
Disease
Displaying entries 1 - 10 of 11 in total
DO ID Disease Name Source
DOID:10763 hypertension
DOID:1588 thrombocytopenia
DOID:2215 factor VII deficiency
DOID:2913 acute pancreatitis
DOID:3393 coronary artery disease
DOID:3526 cerebral infarction
DOID:5844 myocardial infarction
DOID:9256 colorectal cancer
DOID:9352 type 2 diabetes mellitus
DOID:9744 type 1 diabetes mellitus
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025