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Alpha-2A adrenergic receptor

Summary

UniProt ID

P08913

Gene Symbol

ADRA2A
ADRA2R
ADRAR

Organism

Homo sapiens (human)

External Links

GlyGen: P08913
PubChem: P08913
The Human Metabolome Database: HMDBP01601
The O-GlcNAc Database: P08913

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 42 in total

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GO Term
Rho protein signal transduction
negative regulation of norepinephrine secretion
platelet activation
negative regulation of epinephrine secretion
cellular response to hormone stimulus
negative regulation of insulin secretion
thermoception
negative regulation of lipid catabolic process
negative regulation of calcium ion transport
negative regulation of insulin secretion involved in cellular response to glucose stimulus

Displaying entries **1 - 10** of 11 in total

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GO Term
postsynaptic density membrane
neuronal cell body
receptor complex
axon terminus
dopaminergic synapse
glutamatergic synapse
GABA-ergic synapse
presynaptic active zone membrane
basolateral plasma membrane
cytoplasm

Displaying **all 10** entries
GO Term
heterotrimeric G-protein binding
protein kinase binding
epinephrine binding
norepinephrine binding
alpha-1B adrenergic receptor binding
alpha-2C adrenergic receptor binding
thioesterase binding
protein homodimerization activity
protein heterodimerization activity
alpha2-adrenergic receptor activity

Annotation information from UniProt.

Sequence

MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	GlyTouCan ID	Source
25	N-linked (GlcNAc...) asparagine		UniProt GlyGen
29	N-linked (GlcNAc...) asparagine		UniProt GlyGen
		G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Adrenaline signalling through Alpha-2 adrenergic receptor	Homo sapiens
Adrenaline,noradrenaline inhibits insulin secretion	Homo sapiens
Adrenoceptors	Homo sapiens
G alpha (i) signalling events	Homo sapiens
G alpha (z) signalling events	Homo sapiens
Surfactant metabolism	Homo sapiens