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Cyclic AMP-responsive element-binding protein 1

Summary

UniProt ID

P15337

Gene Symbol

Creb1
Creb-1

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P15337
PubChem: P15337
The O-GlcNAc Database: P15337
O-GlcNAcAtlas: P15337

Annotation

Keyword

3D-structure
Activator
Alternative splicing
Biological rhythms
DNA-binding
Differentiation
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

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GO Term
hormone secretion
pituitary gland development
response to glucagon
positive regulation of multicellular organism growth
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of fat cell differentiation
positive regulation of osteoclast differentiation
positive regulation of hormone secretion

Displaying **all 9** entries
GO Term
ATF4-CREB1 transcription factor complex
mitochondrial matrix
nucleoplasm
transcription regulator complex
RNA polymerase II transcription regulator complex
chromatin
euchromatin
nucleus
axon

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GO Term
DNA binding
enzyme binding
histone acetyltransferase binding
cAMP response element binding
RNA polymerase II-specific DNA-binding transcription factor binding
arrestin family protein binding
Hsp70 protein binding
identical protein binding
transcription cis-regulatory region binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding

Annotation information from UniProt.

Sequence

MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	GlyTouCan ID	Source
40	G49108TO	GlyGen The O-GlcNAc Database
245	G49108TO	GlyGen
246	G49108TO	GlyGen
247	G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
AKT phosphorylates targets in the nucleus	Rattus norvegicus
CREB phosphorylation	Rattus norvegicus
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	Rattus norvegicus
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Rattus norvegicus
Gastrin-CREB signalling pathway via PKC and MAPK	Rattus norvegicus
NCAM signaling for neurite out-growth	Rattus norvegicus
NGF-stimulated transcription	Rattus norvegicus