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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
N-acetylglucosamine-6-sulfatase
Summary
- UniProt ID
- P15586
- Gene Symbol
-
- GNS
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011554
- GlyConnect
- GlyGen
- P15586
- PubChem
- P15586
- The Human Metabolome Database
- HMDBP01597
- The O-GlcNAc Database
- P15586
- O-GlcNAcAtlas
- P15586
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Hydrolase
- Lysosome
- Metal-binding
- Mucopolysaccharidosis
- Phosphoprotein
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| glycosaminoglycan catabolic process |
| keratan sulfate catabolic process |
| GO Term |
|---|
| azurophil granule lumen |
| lysosomal lumen |
| ficolin-1-rich granule lumen |
| extracellular region |
| extracellular exosome |
| GO Term |
|---|
| sulfuric ester hydrolase activity |
| N-acetylglucosamine-6-sulfatase activity |
| glycosaminoglycan binding |
| metal ion binding |
| sulfate binding |
Sequence
MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 278 |
|
|||
| 279 | N-linked (GlcNAc...) asparagine | |||
| 317 | N-linked (GlcNAc...) asparagine | |||
| 362 | N-linked (GlcNAc...) asparagine |
|
||
| 387 | N-linked (GlcNAc...) asparagine | |||
| 404 |
|
|||
| 405 | N-linked (GlcNAc...) asparagine | |||
| 407 |
|
|||
| 422 | N-linked (GlcNAc...) asparagine | |||
| 449 | N-linked (GlcNAc...) asparagine |
G49108TO
G56770VP
G83460ZZ
G92406TI
G46503DX
G70101JE
G80920RR
G59924QI
G62765YT
G28541PG
G72735IY
G05724UK
G31852PQ
G90575OW
G39446WN
G39188ZX
G41247ZX
G50282JC
G02815KT
G06110VR
G84349RE
G92050GC
G14669DU
G09528DL
G10773YW
G72787SB
G15664MX
G27126ED
G51640FO
G70223PD
G49018RC
G01650EU
G01485JJ
G02886BB
G23863VK
G64527OM
G95995BI
G47644PP
G33609NS
G25637MV
G00406II
G74724QE
G92275SC
G37995HC
G71463BG
G18183SM
G31544HA
G30769VJ
G90382BL
G92135MA
G34989PA
G45395BF
G37412TK
G08918WF
G78790NZ
G64409MC
G37399XV
G23719VF
G35541EV
G28681TP
G58001LT
G52890YB
G57888GL
G26915XM
G02628JF
G57317CE
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Keratan sulfate degradation | Homo sapiens |
| Lysosome Vesicle Biogenesis | Homo sapiens |
| MPS IIID - Sanfilippo syndrome D | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110307 | hypertrophic cardiomyopathy 1 | |
| DOID:0111390 | mucopolysaccharidosis Ih | |
| DOID:0111393 | mucopolysaccharidosis type IIIC | |
| DOID:0111394 | mucopolysaccharidosis type IIIB | |
| DOID:0111395 | mucopolysaccharidosis type IIIA | |
| DOID:0111402 | mucopolysaccharidosis type IIID | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:1059 | intellectual disability | |
| DOID:11832 | visual epilepsy | |
| DOID:12798 | mucopolysaccharidosis |
