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Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS raw data Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Syndecan-1
Summary
- UniProt ID
- P18827
- Gene Symbol
-
- SDC1
- SDC
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P18827
- PubChem
- P18827
- The Human Metabolome Database
- HMDBP02143
- The O-GlcNAc Database
- P18827
- O-GlcNAcAtlas
- P18827
Annotation
- Keyword
-
- 3D-structure
- Heparan sulfate
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular exosome |
| Golgi lumen |
| external side of plasma membrane |
| cell surface |
| lysosomal lumen |
| plasma membrane |
| protein-containing complex |
| GO Term |
|---|
| identical protein binding |
| cargo receptor activity |
Sequence
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 37 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 43 | N-linked (GlcNAc...) asparagine |
|
||
| 45 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 47 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 58 |
|
|||
| 61 |
|
|||
| 63 |
|
|||
| 64 |
|
|||
| 72 |
|
|||
| 76 |
|
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| Attachment and Entry | Homo sapiens |
| Cell surface interactions at the vascular wall | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | Homo sapiens |
| Defective EXT2 causes exostoses 2 | Homo sapiens |
| HS-GAG biosynthesis | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:65 | connective tissue disease | |
| DOID:6536 | plasma cell neoplasm | |
| DOID:657 | adenoma | |
| DOID:6688 | autoimmune lymphoproliferative syndrome | |
| DOID:6713 | cerebrovascular disease | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:707 | B-cell lymphoma | |
| DOID:7148 | rheumatoid arthritis | |
| DOID:7442 | monoclonal gammopathy of uncertain significance | |
| DOID:7551 | gonorrhea |
