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Cyclic AMP-dependent transcription factor ATF-4

Summary

UniProt ID

P18848

Gene Symbol

ATF4
CREB2
TXREB

Organism

Homo sapiens (human)

External Links

GlyGen: P18848
PubChem: P18848
The Human Metabolome Database: HMDBP08114
The O-GlcNAc Database: P18848

Annotation

Keyword

3D-structure
Acetylation
Activator
Biological rhythms
Cell membrane
Coiled coil
Cytoskeleton
DNA-binding
Hydroxylation
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying entries **31 - 40** of 45 in total

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GO Term
positive regulation of transcription by RNA polymerase II
positive regulation of vascular endothelial growth factor production
endoplasmic reticulum unfolded protein response
response to endoplasmic reticulum stress
circadian regulation of gene expression
cellular response to amino acid starvation
PERK-mediated unfolded protein response
cellular response to glucose starvation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
integrated stress response signaling

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GO Term
cytosol
nuclear periphery
nucleoplasm
centrosome
RNA polymerase II transcription regulator complex
chromatin

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GO Term
DNA binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
general transcription initiation factor binding
cAMP response element binding protein binding
protein kinase binding
RNA polymerase II-specific DNA-binding transcription factor binding
promoter-specific chromatin binding
identical protein binding

Annotation information from UniProt.

Sequence

MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSEWLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTCDLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
ATF4 activates genes in response to endoplasmic reticulum stress	Homo sapiens
ATF6 (ATF6-alpha) activates chaperone genes	Homo sapiens
NFE2L2 regulating ER-stress associated genes	Homo sapiens
NFE2L2 regulating anti-oxidant/detoxification enzymes	Homo sapiens
PERK regulates gene expression	Homo sapiens
Response of EIF2AK1 (HRI) to heme deficiency	Homo sapiens
Response of EIF2AK4 (GCN2) to amino acid deficiency	Homo sapiens